Last Updated on May 30, 2023
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The active ingredient Valsartan is a member of sartans which inhibit the action of the hormone angiotensin in the body and thus lowering blood pressure. It is used in first line treatment of hypertension. Moreover Valsartan may be used in patients with myocardial infarction or heart failure. Here you can read everything about the effect of Valsartan, side effects and use.
How Valsartan works
The salt and water balance in the human body is regulated by the hormonal RAA system (renin-angiotensin-aldosterone). At the same time the blood pressure is thus regulated: If a lot of fluid was added (for example, by frequent drinking), must be submitted via the kidneys more so the filling volume does not increase too much in the blood vessels. Whoever eats something very salty, gets thirsty – the body craves fluids to keep the salt concentration in the body in the normal value
Angiotensin II is one of the hormones in this system. When it binds to its receptors on the inside of blood vessels, the vessels constrict – the blood pressure rises. Also, in the kidney there is angiotensin II receptors: Here the hormone ensures that less salt is discharged into the urine, or more salt water and thus remains in the body. This also makes the blood pressure rises.
Valsartan blocks the angiotensin II receptors, so that the hormone is unable to exert its effect. This prevents an increase in blood pressure and relieves the heart.
Pharmacokinetics and metabolism of Valsartan
After taking Valsartan tablets, the highest drug concentrations found after two to four hours in the blood, in solving the revenue after only one to two hours. Overall, the inclusion of the intestine into the blood, the so-called bioavailability, but very low at tablets only about 25 percent, in the solution at about 40 percent.
In the body, a fifth of the amount of active ingredient is about metabolised to inactive degradation products, the rest is excreted unchanged. Excretion is mainly via the bile in the feces. About six hours after taking half the amount administered has been eliminated.
When is Valsartan used?
The active ingredient Valsartan is used to treat heart failure and (heart failure) when this can not be through other medicines to treat sufficiently well.
The application of the high blood pressure medicine takes place normally long-term.
How Valsartan is taken?
The most common application form of Valsartan tablets are for oral use. For patients who suffer from dysphagia or be fed through a tube, are solutions for oral use are available.
The Valsartan dosage is highly dependent on the application and is usually between 80 and 160 milligrams of active ingredient once a day. The maximum dose is 320 milligrams. Sometimes these daily dose is divided between two income (morning and evening).
To achieve a stronger hypotensive effect Valsartan can be combined with additional antihypertensive agents. These are combination preparations with, for example, Valsartan and Amlodipine and / or Hydrochlorothiazide (HCT) is available.
What are the side effects of Valsartan?
In controlled clinical trials, Valsartan did not solve common side effects from the drug-free placebos (placebos). In one of hundreds to thousands of those treated it came as common Valsartan side effects.
Fast withdrawal of Valsartan does not, unlike some other antihypertensive drugs to increased blood pressure rise (so-called “rebound effect”).
The often triggered by blood pressure medication erectile dysfunction occurs when Valsartan generally on not. Sometimes can sartans such as Losartan and Valsartan impotence (Erectile Dysfunction) even have a positive effect.
What should I watch for while taking Valsartan?
The additional intake of another on the RAA system or blood pressure acting drugs should be closely monitored by your doctor especially at the beginning, so that the blood pressure does not drop too much.
Since the mood stabilizing agents lithium should not or only under strict control of blood levels are used concomitantly with Valsartan. Namely, it is transported similar to sodium in the body, and Valsartan influenced sodium excretion and recovery.
In combination with products that may increase potassium levels in the body, potassium levels should be monitored. Such preparations are, for example, potassium-sparing diuretics and potassium supplements. Even low-sodium salt is one of them.
With the concurrent use of NSAIDs such as aspirin or Ibuprofen for one, the antihypertensive effect is reduced. Secondly, the kidney function may deteriorate and increase the levels of potassium in the blood.
In patients with renal impairment, Valsartan therapy should be strictly monitored by the doctor. The same applies in patients with mild to moderate hepatic impairment.
Pregnancy and lactation
Since Valsartan may harm the unborn baby, the antihypertensives in pregnancy may – especially in the second and third trimester of pregnancy – not be used
About the use of Valsartan during breastfeeding is no information at. Nursing mothers should not take Valsartan therefore.
How to get Valsartan
drugs Valsartan are subject to prescription and can be purchased only in pharmacies.
Since when Valsartan is known?
The first Sartan – Losartan – launched in 1995 in the United States by the pharmaceutical company Merck to market. Later, other drugs have been developed which are utilized, among other things better in the body and have a longer effect. Thus, Valsartan has a longer duration of action and often more selective site of action on inhibition as Losartan. Valsartan was by the pharmaceutical company Ciba-Geigy AG (now Novartis) patented in 1991 and is now contained in various medicines.