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Amlodipine is a long-acting antihypertensive drugs from the group of calcium channel blockers (calcium antagonists). It is used for high blood pressure, certain cases of angina pectoris (heart Enge) and in coronary heart disease. Amlodipine reduces the oxygen demand of the heart and dilates the arteries. Thereby, the blood pressure drops. . Read more about interesting facts about Amlodipine more here – dosage, side effects, application notes
How Amlodipine works
Amlodipine is a calcium channel blocker (calcium antagonist): It inhibits certain calcium channels, thereby preventing the calcium influx into myocardial cells and vascular smooth muscle. This reduces on the one hand the oxygen demand of the heart. Second, the vessel walls relax: The arteries and arterioles (smallest arteries) dilate, which lowers blood pressure
The antihypertensive effect of Amlodipine is a 30 to 50 minutes after ingestion and lasts for about 24 hours. The liver takes care of the degradation of the active ingredient, the kidneys do not assume excretion. This metabolism takes very long: it pass 35 to 50 hours until the half of the captured drug was excreted (elimination half-life)
When is Amlodipine applied
The fields of application (indications) of.? Amlodipine are:
- chronic stable heart Enge ()
- vasospastic angina, also called Prinzmetal angina (special form of heart Enge, when it comes through a temporary contraction of heart disease vessels to hypoperfusion of the heart muscle)
How to take Amlodipine
The high blood pressure medicines is taken in oral dosage form, especially a tablet. The Amlodipine-active substance is contained there as salt, so for example, as Amlodipine besylate or Amlodipine. Because degradation and excretion of the drug take so long, is generally sufficient to a once daily regimen.
What are the side effects of Amlodipine?
Possible Amlodipine side effects include drowsiness, fatigue, dizziness and headache (especially at the beginning of treatment).
Due to the widening of the blood vessels may lead to an increased excretion of fluid into the tissue. This may result in fluid retention (edema) in arms and legs.
More Amlodipine side effects that may occur are for example heart rate (tachycardia), palpitations (palpitations) and a strengthening of existing angina pectoris. Also abdominal pain, nausea, vomiting and cause. Some patients develop (dyspnoea) during treatment joint and muscle pain, cramps, problems urinating, increased sweating and breathing difficulties. Also possible are, inter alia, insomnia, mood swings, taste and vision problems, weight changes, tremors and abnormal sensations (paresthesia).
What should be considered when taking Amlodipine?
During a hypersensitivity against the substance group of dihydropyridines, which included Amlodipine heard of antihypertensives should not be used. More Contraindications (contraindications) for taking the blood pressure medicine are cardiovascular shock, a higher-grade narrowing of the aorta (aortic stenosis), unstable angina, acute myocardial infarction and severe hepatic dysfunction.
In acute heart failure (congestive heart failure) is not recommended the application.
In kidney patients, who depend on dialysis, Amlodipine should be used with caution.
The use in pregnancy and lactation has not been adequately studied and should therefore be considered with caution. If possible, should be avoided to better proven alternatives.
Since Amlodipine is cleared predominantly by a certain liver enzyme system, there may be interactions with other drugs that inhibit this enzyme system sustainable or activate. These include, for example, Phenytoin and Carbamazepine (medicines for epilepsy), rifampicin (antibiotic used against tuberculosis), St John’s wort extracts (with depressed mood), ritonavir (for HIV infection), voriconazole (to treat fungal infections) and Clarithromycin (antibiotic).
With simultaneous use of certain antidepressants (tricyclic antidepressants) intensified the antihypertensive effect. The same applies to nitrates (used to treat angina).
The combination with cardiovascular agents from the group of beta blockers in patients with heart failure reinforced the symptoms.
In general: For safety’s sake should tell their doctor or pharmacist patient if they want to take next Amlodipine nor other medications (including non-prescription)
How to obtain medicines containing the active ingredient Amlodipine
Amlodipine is a prescription medication and only in the pharmacy to buy.