Last Updated on June 3, 2023
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The active ingredient Omeprazole is one of the best known and most prescribed drugs for the treatment of heartburn and ulcers and inflammation of the stomach, esophagus and duodenum. Omeprazole acts on the gastric mucosa, where it inhibits the production of stomach acid. With some exceptions, the income is not a problem, as the drug is very well tolerated and rarely side effects even at high doses. Read more about the effect of Omeprazole, side effects and use.
How Omeprazole works
The Omeprazole drug is absorbed and from there through the bloodstream to the following oral administration in the small intestine parietal cells of the gastric mucosa. These are (mainly consisting of hydrochloric acid) responsible for the production of stomach acid. In these cells by blocking an enzyme which is called proton pump. It “pumps” protons as part of the hydrochloric acid in the stomach area. Ultimately Omeprazole inhibits acid production thus irreversibly, making the environment in the stomach is less acidic. The extent of gastric acid output inhibition is dose-dependent.
DA Omeprazole only reacts as a so called “prodrug” at its site of action in an acidic environment to the active form, it can be ensured that the active form only acts on the gastric mucosa and no other cells affected.
When is Omeprazole applied?
Omeprazole is used to treat and prevent the recurrence of inflammation and ulcers of the sections oesophageal, stomach and small intestine used. Main applications are:
- increased production of gastric acid (hyperacidity)
- gastritis (gastritis)
- inflammation of the esophagus caused by reflux of gastric juice (reflux oesophagitis)
- ulcers in the duodenum (duodenal ulcer)
- ulcers in the stomach (gastric ulcer)
Another area of application of the gastric acid inhibitor is the so-called Zollinger-Ellison syndrome – a disease with tumor conditionally increased gastric acid production due to a hormonal hyperstimulation of the parietal cells
In addition, the gastric acid inhibitor is integrated in the treatment of a Helicobacter pylori infection. It is a bacterium that infects the stomach lining and a pathologically increased gastric acid production causes, which can lead to stomach ulcers, Breakthroughs and tumors.
How to take Omeprazole
the treatment of acute diseases of stomach acid inhibitor is taken orally as gastroresistant capsule or tablet, as it happen for its effect the stomach and should be dissolved and absorbed in the small intestine. The usual dosage of Omeprazole is 20 to 40 milligrams per tablet or capsule. Most in the self-medication the drug more than two weeks is taken once a day. The Omeprazole intake is recommended in the morning 30 minutes before breakfast on an empty stomach. If it has not yet come after two weeks of treatment, an improvement of symptoms, the patient should go to the doctor. In the acute treatment with Omeprazole therapy may also be prescribed in higher doses by a doctor.
For the treatment of Helicobacter pylori infection of the gastric acid inhibitor is administered together with a combination of antibiotics (Clarithromycin and Azithromycin).
In general, it should be noted here that Omeprazole only treats symptoms but not the cause. A doctor must clarify this and initiate appropriate treatment.
What are the side effects of Omeprazole?
Omeprazole is very well tolerated. Every tenth to hundredth patient develops gastrointestinal symptoms (such as, flatulence) as side effects of treatment. The reason: The bacterial populations in the gut can not be so heavily regulated by the gastric acid under the influence of gastric acid inhibitor
Similarly, how often gastrointestinal symptoms also occur, dizziness, fatigue and sleep disturbances than Omeprazole side effects. In addition, the digestion is made difficult by the reduced gastric acid production. This can be explained by the fact that many digestive enzymes work optimally only at the low pH of the stomach acid. Of these, especially enzymes are involved which are responsible for the degradation of proteins (proteins).
When to Omeprazole not take?
Omeprazole is not suitable for children under two years. In addition, it should not be used during pregnancy or breast-feeding, if possible. In addition, pre-existing conditions of the liver are an exclusion criterion for taking the gastric acid inhibitor.
is not recommended for concurrent administration of the anticoagulant Clopidogrel. Omeprazole inhibits namely the enzyme that activates Clopidogrel, so its effect can not be guaranteed.
In addition, the gastric acid inhibitors affect the metabolism of the following medications:
- Clopidogrel (blood thinner)
- Diazepam (a sedative)
- Phenytoin (antiepileptic)
- Warfarin (anticoagulant)
How to buy Omeprazole online OTC
The active ingredient may in packs of up to 14 (corresponding to a daily intake of up to two weeks) purchased at a maximum of 20 milligrams of Omeprazole without prescription at the pharmacy become. In higher doses, Omeprazole is only available on prescription.
Since when Omeprazole is known?
Omeprazole was launched in 1989 in the US market. It was the first proton pump inhibitor used therapeutically and became in the 90s the flagship of the pharmaceutical company AstraZeneca, yielded by the first Omeprazole preparations annual profits in the billions.