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Last Updated on March 16, 2024

Most online pharmacies offer Ranitidine 150, 300 mg. First read recommendations on purchasing drugs online in the event you intend to purchase Ranitidine online.

Ranitidine over the counter is a medication used to treat acid reflux and heartburn. It works by reducing the amount of acid produced in the stomach, helping to relieve discomfort and pain. Although prescription-strength ranitidine is available, many people choose the over-the-counter version because it is more convenient and cost-effective.

In the UK, over-the-counter ranitidine is available from most pharmacies and some supermarkets. It is important to note that although it is easy to obtain, individuals should still consult their healthcare professional before taking ranitidine, especially if they are pregnant, breastfeeding or have other medical conditions. Those with kidney or liver disease, allergies, or taking other medications should also seek medical advice before taking ranitidine.

Overall, over-the-counter ranitidine can be an effective solution for people who suffer from acid reflux or heartburn. However, it is important to use the medication as directed and to seek medical advice if symptoms persist or worsen.

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What is Ranitidine?

The blocker of histamine H2-receptors. Suppresses the basal and stimulated by histamine, gastrin and acetylcholine (to a lesser extent) the secretion of hydrochloric acid. It increases the pH of gastric contents and reduces the activity of pepsin. The duration of action ranitidine with a single admission – 12 hours. The active ingredient Ranitidine is one of the drugs to treat heartburn and peptic ulcers. Because it is not as potent as other drugs against these diseases, Ranitidine is used only as a means of second choice. Children and pregnant women should not take the drug after a detailed medical examination. Here you can read everything about Ranitidine.

How Ranitidine works?

Once inside, ranitidine is rapidly absorbed from the digestive tract. Food intake and antacids slightly affect the degree of absorption. Exposed to the effect of “first passage” through the liver. Cmax in plasma is achieved 2 hours after a single oral intake. After the / m introduction quickly and almost completely absorbed from the injection site. Cmax is reached after 15 minutes.

Binding to proteins – 15%. Vd – 1.4 l / kg. Ranitidine is excreted in breast milk.

T1 / 2 is 2-3 hours. About 30% of the dose is excreted unchanged in the urine. The rate of excretion is reduced if the liver or kidney function is impaired.

Especially in the fasting state, the gastric environment is very acidic. This is important, since the ingested food must meet a mix of acid and enzymes to ensure a first digestion and bacterial killing. In order to maintain this environment, the body has a complex control mechanism, to which various neurotransmitters such as histamine and acetylcholine (acid-stimulating) and prostaglandins (acid-resistant) are involved.

Normally, the aggressive gastric acid would attack the wall of the stomach, if it were not protected. That protection is an acid-neutralizing mucus is mainly involved, which is like a film on the stomach inner wall.

In some cases, however, this protection could be affected or are inadequate. The acid can then cause by attacking the stomach wall an ulcer. In addition, when it comes to heartburn regurgitation: Acid stomach contents rise up (reflux) and comes with the unprotected esophageal mucosa in contact. An inflammation of the esophagus is the possible consequence (reflux oesophagitis).

Ranitidine belongs to the so-called H 2antihistamines and inhibits the production of acid in specific cells (parietal cells) of the stomach. There, the active agent blocks the docking sites (receptors) from the acid-stimulating histamine, resulting in less acid is pumped into the gastric compartment. As a result, the gastric environment is less acidic, which relieves the symptoms.

Pharmacokinetics and metabolism of Ranitidine

After recording via the mouth (oral), the active ingredient in a sufficient amount from the intestine is absorbed into the blood. The maximum effect occurs after about two hours. After its distribution in the body Ranitidine is metabolised in the liver. The degradation products are then excreted by the kidneys.

When is Ranitidine prescribed?

Stomach ulcer and duodenal ulcer in the phase of exacerbation; prevention of exacerbations of peptic ulcer; symptomatic ulcers; erosive and reflux esophagitis; Zollinger-Ellison syndrome; prevention of “stressful” gastrointestinal ulcers, postoperative ulcers, relapses of bleeding from the upper gastrointestinal tract; prevention of aspiration of gastric juice during surgery under anesthesia.

Among the areas of application (indications) of Ranitidine include:

  • short-term treatment of heartburn and acid-related esophageal inflammation (reflux esophagitis)
  • gastrointestinal ulcers

How to take Ranitidine?

Usually, Ranitidine is applied in the form of tablets. The usual dose ranges from 75 milligrams (short-term treatment of heartburn) to 300 milligrams (in acute gastrointestinal ulcers). The tablets may be taken with or without a meal, sometimes a dose is recommended right after eating before going to bed.

Dosage

Install individually. Inside for the treatment of adults and children over 14 years of age use in a daily dose of 300-450 mg, if necessary, the daily dose is increased to 600-900 mg; the frequency of reception is 2-3 times/day. For the prevention of exacerbations of diseases apply 150 mg/day before bedtime. The duration of treatment is determined by indications for use. Patients with renal insufficiency with a creatinine level of more than 3.3 mg/100 ml – 75 mg 2 times/day.

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In/in or /m – for 50-100 mg every 6-8 hours.

Do you treat heartburn with Ranitidine itself over a period of 14 days. Then should not have improved the symptoms, a medical examination is suggested.

Side effects

Often, that is at more than ten percent of those treated, can cause such side effects Ranitidine. This is mainly due to the increase in the number of bacteria in the stomach, because less acid in the stomach is a destruction of the bacteria in the food available.

It may occasionally on by taking Ranitidine to head, and joint and cardiac arrhythmias.

Ranitidine for violations of kidney function

Use with caution in patients with impaired renal excretion.

Use in children

Clinical data on the safety of ranitidine in pediatrics are limited.

Special instructions

Use with caution in patients with impaired renal excretion.

Before starting treatment, it is necessary to exclude the possibility of malignant disease of the oesophagus, stomach or duodenum.

Long-term treatment in weakened patients under stress may cause bacterial lesions of the stomach with subsequent spread of infection.

It is undesirable to stop taking ranitidine abruptly because of the risk of recurrence of peptic ulcer. The effectiveness of preventive treatment of peptic ulcer is higher when ranitidine is taken in 45-day courses in the spring and autumn than when it is taken continuously. Rapid intravenous administration of ranitidine rarely causes bradycardia, usually in patients predisposed to arrhythmias.

There have been anecdotal reports that ranitidine may contribute to the development of an acute attack of porphyria, and it is therefore necessary to avoid its use in patients with a history of acute porphyria.

The use of ranitidine may cause distortions in laboratory data: an increase in the level of creatinine, GGT activity and liver transaminase in blood plasma.

In cases where ranitidine is used in combination with antacids, the interval between antacid intake and ranitidine intake should be at least 1-2 hours (antacids may interfere with ranitidine absorption).

Clinical data on the safety of ranitidine in children are limited.

Drug Interactions

  • Co-administration with antacids may reduce the absorption of ranitidine.
  • Co-administration with anticholinergics may impair memory and attention in elderly patients.
  • Histamine H2-receptor blockers are thought to reduce the ulcerogenic effect of NSAIDs on the stomach lining.
  • Concomitant use with warfarin may reduce warfarin clearance. A case of development of hypoprothrombinemia and bleeding in a patient receiving warfarin is described.
  • Co-administration of dicitrate with bismuth tricalium may result in an undesirable increase in bismuth absorption; with glibenclamide – cases of development of hypoglycaemia are described; with ketoconazole, itraconazole – absorption of ketoconazole, itraconazole decreases.
  • Co-administration with metoprolol may result in an increase in plasma concentration and an increase in AUC and T1/2 of metoprolol.
  • Concomitant use with sucralfate in high doses (2 g) may interfere with the absorption of ranitidine.
  • Concomitant use with procainamide may decrease renal excretion of procainamide and increase its concentration in blood plasma.
  • There is evidence of increased absorption of triazolam when used concomitantly, apparently due to a change in pH of the stomach contents under the influence of ranitidine.
  • Co-administration with phenytoin is thought to increase the plasma concentration of phenytoin and may increase the risk of toxicity.
  • Co-administration with furosemide has been associated with a moderate increase in furosemide bioavailability.
  • A case of development of ventricular arrhythmias (bigemini) has been described with concomitant use of quinidine; with cisapride – a case of development of cardiotoxicity has been described.
  • A slight increase in the concentration of cyclosporine in the blood plasma cannot be excluded when it is used simultaneously with ranitidine.
  • Medication with ranitidine should not be used if the patient suffers from a certain metabolic disorder (porphyria).

Interaction

In a concomitant use of ranitidine may increase the effect of the following medications:

  • Diazepam (for insomnia)
  • lidocaine, procainamide (for irregular heart beat)
  • Phenytoin (for epilepsy)
  • Propranolol (at)
  • Theophylline (shortness of breath diseases such as asthma)
  • Warfarin, phenprocoumon (blood thinners)

By changing the gastric environment, it may happen that the following active substances are absorbed better, which enhances their effect:

  • Triazolam, midazolam (sedatives)
  • Glipizide (diabetes)

The inclusion of the following medications is decreased by Ranitidine, which can lead to a weakening of action:

  • Ketoconazole (for fungal infections)
  • Atazanavir, delavirdine (HIV-disease)
  • Gefitinib (in cancer)

Driving and using machines

You may get dizzy or have trouble concentrating. You should therefore wait and see how your body reacts to the drug before deciding whether or not to drive with your doctor.

This is especially true if you drink alcohol as ranitidine slows down the metabolism of alcohol.

Parental

Without doctor’s advice medicines containing ranitidine should not be used in children under 16 years of age. If children or teenagers experience symptoms such as acid reflux or stomach pain, a doctor should always be consulted.

Pregnancy and lactation

Medication containing ranitidine may be used by pregnant and breastfeeding women after a rigorous risk-benefit assessment if neutralising medicines have not been successful in treating heartburn.

Experience has shown that ranitidine is very well tolerated and does not cause any harm to your baby or infant. It is therefore the treatment of choice for pregnant and breastfeeding women.

Where to buy ranitidine?

Low-dose ranitidine tablets (75 milligrams per tablet) are available over the counter from pharmacies. However, for long-term and higher dose treatment, a doctor’s prescription is required to ensure regular monitoring of therapeutic success. However, you can buy Ranitidine 150 & 300 mg OTC online.

Since when ranitidine is known?

Ranitidine has been around for a relatively long time. However, like the so-called proton pump inhibitors (omeprazole, pantoprazole), a class of drugs that are stronger and more effective in treating heartburn and stomach ulcers, ranitidine is only used as a second-line treatment.

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