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Last Updated on March 16, 2024

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The active ingredient Pantoprazole belongs as a proton pump inhibitor to the main agents used to treat heartburn and stomach ulcers. Frequently it is also used as a gastric protection in addition to treatment with certain painkillers, which can irritate the stomach. The proton pump inhibitors came in 1994 on the market. Since 2009 Pantoprazole is available without a prescription for self-medication. Here you can read everything about the active substance Pantoprazole, side effects and application notes.

How Pantoprazole works

The human stomach produces to digest the food components stomach acid (the main component thereof is hydrochloric acid). He, however, not even digested, the stomach lining is also from a tough secretion which protects the cells of the mucosa against the aggressive acid. The lining of the esophagus is protected from the strong irritating stomach acid by a sphincter at the entrance to the stomach (esophageal sphincter).

If too much acid is formed and / or the sphincter is not functioning properly, gastric acid can pass into the esophagus and may attack the local mucosa. It comes to pain (heartburn) and inflammation (esophagitis).

The stomach acid may also be to blame if an existing or only very slowly heals by constantly irritates the tissue.

proton pump inhibitor

The active ingredient Pantoprazole inhibits the so-called proton pump, which are responsible for the secretion of gastric acid in the stomach lining. He has to be transported through the bloodstream to the stomach for this, however. Only there it is converted by stomach acid to the active drug form which then inhibits the proton pump. For this reason, Pantoprazole is taken in the form of enteric-coated tablets that release the active ingredient only in the intestine where it is absorbed into the blood. Therefore, it must be ensured in the Pantoprazole taking out the tablets whole shares and take without chewing.

The effect of Pantoprazole not immediately relieves the discomfort, but acts over a few days – after two to three days, the maximum effect is generally achieved. This should be considered when self-medication.

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When is Pantoprazole applied?

Pantoprazole is employed in order to reduce the endogenous production of gastric acid. This is necessary for heartburn, inflammation of the esophagus by stomach acid rising (reflux esophagitis) and to promote the regression of gastric ulcers.

Furthermore, combinations of Pantoprazole and antibiotics usually used to treat an infection with the bacterium Helicobacter pylori. Left untreated can cause stomach ulcers and even germ of gastric cancer.

Pantoprazole is also often used as adjunctive therapy in the long term treatment with non-steroidal anti-inflammatory drugs (NSAIDs). These painkillers often cause gastric acid-associated side effects. Pantoprazole can protect yourself.

The proton pump inhibitor is used both for short-term therapy as well as for longer-term treatment, the latter, however, only on doctor’s orders.

How Pantoprazole is taken?

Most Pantoprazole is administered as enteric tablet, rare as an injection solution.

The tablet is usually taken in the morning on an empty stomach about an hour before breakfast with a glass of water. For acute symptoms, a second dose is in consultation with the doctor taken in the evening, possibly also several tablets at a time when higher Pantoprazole dosage is necessary.

What are the side effects of Pantoprazole?

In general, occur in the treatment with Pantoprazole side effects only rarely. Approximately one percent of patients experience or diarrhea.

Especially with long-term use of proton pump inhibitor (a year or longer) an increase in liver enzymes, vitamin B 12deficiency, magnesium deficiency and bone fractures (especially in the elderly) possible. Side effects such as these also occur under other proton pump inhibitors.

Symptoms of overdose in humans are not known.

What should I watch for while taking Pantoprazole?

For children under the age of 12 Pantoprazole should not be used due to lack of experience.

During pregnancy, Pantoprazole must not be used as the active ingredient in animal studies reprotoxic (toxic for reproduction) was. As Pantoprazole is excreted in human breast milk, a doctor should be breast-feeding before taking be questioned.

Pantoprazole can change the recording speed of other medicines. Especially potent drugs (eg opiates such as morphine) are so unaccustomed rapidly absorbed from the intestine, resulting in higher blood levels. Therefore it should be held in front of the concurrent use of Pantoprazole and other drugs consulting a doctor or pharmacist.

How to get medicines with Pantoprazole

The active ingredient Pantoprazole can be ordered in Germany as a medicinal product exclusively through the pharmacy.

Since 2009, tablets containing up to 20 milligrams of Pantoprazole are prescription in Germany, however, only in packs of 7 and 14 tablets. This is to prevent that patients are taking on your own the proton pump inhibitor in the long term. Higher-dose tablets (40 mg) and injection solutions are available on prescription.


The active ingredient Pantoprazole came only after the drug (the first proton pump inhibitor) on the market and is an analog product, that is, the areas of application and mode of action are almost identical.

More interesting information

The intake of Pantoprazole can be a false positive result in a quick test for THC, the psychoactive component of marijuana result / cannabis.

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