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Erythromycin
The active ingredient Erythromycin belongs to the class of macrolide antibiotics and is used to treat bacterial infections. After covering a similar range of effects such as penicillin, it is often used as a substitute for a penicillin allergy. Erythromycin is generally well tolerated, but can with some other drugs cause undesirable interactions. Here you can read everything about Erythromycin, Dosage and administration.
How Erythromycin works
macrolide antibiotics such as Erythromycin inhibit microbial growth on the bacteria, therefore have a bacteriostatic effect. In order to grow, bacteria need (as well as other organisms) produce proteins. The blueprints for proteins is stored in DNA. Erythromycin prevents the bacteria from the read information of her heritage, so that no protein synthesis is possible – the bacteria can not grow. You do not die from this way though. The immune system of the patient but it can bring better and faster control, which spread and aggravation of the infection is usually prevented.
When applied to the skin as a cream or Erythromycin Erythromycin ointment, the active ingredient is hardly absorbed in the organism.
The in tablets or capsules Erythromycin (partially enteric) contained is usually chemically modified so that it will not be immediately destroyed by the stomach acids and also better absorbed in the intestine. Examples of such variants are Erythromycin ethylsuccinate or Erythromycin lactobionate. Despite these changes occur only about 50 percent of the administered amount of active ingredient from the intestine into the blood, where after five hours the highest drug concentration. The antibiotic is very good tissue penetration and reach all areas of the body very well up on the central nervous system (brain and spinal cord). It is metabolized by the liver and partly excreted mainly via the bile in the feces.
When is Erythromycin used?
The applications of Erythromycin include bacterial infections with pathogens that are sensitive to the drug. This information can include, for example, lung infections, whooping cough, infections in the ear, nose and throat area, skin disorders and acne, infections of internal organs and sexually transmitted diseases such as gonorrhea ((syphilis).
How Erythromycin is used
The antibiotic may be in skin disorders such as acne plotted as Erythromycin cream, gel or ointment or applied as a solution. Application is carried out usually twice a day.
The revenue of the antibiotic in the form of tablets, capsules or solutions for drinking or suspensions is usually three to four times a day for a limited period with a Erythromycin dosage up to four grams per day, in children and adolescents correspondingly less.
For the inpatient treatment of severe infections and infusion solutions are available which are administered intravenously.
In order to maximize the impact of antibiotic therapy to achieve, you should strictly adhere to the guidelines for taking. Even with improvement of symptoms, the treatment up to the end must be conducted as an early discontinuation of treatment may lead to a renewed flare-up of infection. Normally, the treatment duration is seven to eight days, in severe infections even up to ten days.
What are the side effects of Erythromycin?
The active ingredient Erythromycin is generally regarded as very few side effects. The most common side effects that occur in one out of ten to one hundred patients gastrointestinal disorders such as on.
Occasionally (ie at about a hundred to a thousand people), it can also lead to elevated liver enzymes, skin reactions and – especially in long-term and repeated dose – get infections of the gastrointestinal tract with resistant pathogens
What should I watch for while taking Erythromycin?
interactions can especially occur when Erythromycin is administered with drugs that are on the same path degraded (CYP450 3A4 enzyme system via) in the liver. This can lead to increased to toxic drug concentrations in the body. Particular caution is therefore advised when combined with:
- the allergy agents terfenadine
- certain agents against psychosis (pimozide, clozapine)
- certain epilepsy agents (Phenytoin, Valproic acid)
- the asthma drug Theophylline
- the sleeping pills and tranquilizers (benzodiazepines) diazepam and midazolam
- antibiotics, which have a similar binding site as Erythromycin, because the effects can pick up (for example, Chloramphenicol, Clindamycin, lincomycin and Tetracycline)
- cholesterol-lowering agents Lovastatin and the
- hormonal contraceptives (“the pill”) – whose effect can be canceled by the antibiotic
The active ingredient Erythromycin can be applied with kidney disease in children aged eight years, the elderly and patients. Patients with liver disease or discomfort should take Erythromycin only after careful medical examination and under the strictest supervision, at best, should be resorted to another antibiotic.
Erythromycin & amp; Pregnancy
The active substance in pregnant women overcomes the placenta and may cause the child to malformations. Pregnant women should therefore whenever possible the antibiotic not take. An application on the skin is, however, possible because the active ingredient is hardly absorbed here above and thus does not pass into the blood.
Since Erythromycin is excreted in breast milk, so nursing mothers stop breastfeeding before starting treatment, to avoid endangering the infant.
How to receive medication with the drug Erythromycin
Because Erythromycin can interact with many other drugs and its use should be carefully considered, in many cases, the antibiotic is available only by prescription in the pharmacy.
Since when Erythromycin is known?
The active ingredient Erythromycin was discovered in soil samples from the Philippine province Iloilo in 1949th After he first received the name “Ilotycin”, was changed this later in “Erythromycin”, since the active substance from the soil bacterium “Streptomyces erythreus” had been won. From 1952 Erythromycin has been marketed by the pharmaceutical company Eli Lilly commercially. It served as a precursor of many newer antibiotics such as Clarithromycin and Azithromycin.