Last Updated on February 8, 2024
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The active ingredient Finasteride is one of the most important ingredients for an enlarged prostate (benign prostatic hyperplasia). The prostate gland is located, or a ring around the head and urethra is enlarged benign in many men older age. In lower dose Finasteride hair loss stops, which is hormonal. The active ingredient is generally considered well tolerated. In rare cases it causes side effects such as sexual dysfunction. Here you can read everything about Finasteride.
Mechanism of Action
For most older men the prostate gland (prostate) is benign enlarged .. Through the pressure of the newly formed tissue in the urethra occurs in many cases to discomfort during urination, frequent nighttime urination, problems with complete emptying of the bladder to Backflow damage with urinary and renal dysfunction.
The hormone testosterone is primarily responsible for the formation of the male sexual characteristics and occurs everywhere in the human body. If testosterone is converted by a specific enzyme (so-called “5-alpha reductase”), produced dihydrotestosterone, which very specifically binds to certain docking sites. Then, a signal is transmitted, which can lead inter alia to tissue proliferation of the prostate gland and in susceptible men.
The drug Finasteride inhibits this enzyme, ie is a so-called “5-alpha reductase inhibitors”. Thus, the concentration drops to dihydrotestosterone. As a result, the size of the prostate decreases and hormonally induced hair loss is stopped.
Pharmacokinetics and metabolism of Finasteride
The drug is almost completely absorbed (about 80 percent) from the intestine into the blood. The effect is about one to two hours. After that Finasteride is metabolized in the liver and excreted in the urine and stool.
When is Finasteride used?
Among the most important fields of application (indications) of Finasteride include:
- Benign tissue proliferation of the prostate gland (benign prostatic hyperplasia)
- hormonally induced hair loss (androgenetic alopecia)
How Finasteride is used
The drug most commonly used form, the tablet is: The active ingredient is here in the core of the tablet and is surrounded by a protective sheath. This prevents that when you touch the tablet active substance is absorbed through the skin.
The Finasteride dose is in men with benign prostatic hyperplasia five milligrams per day. In a treatment of hormonally induced hair loss only one milligram is taken daily. Patients who suffer from liver dysfunction, a reduced dose.
The tablet is taken with or without a meal with sufficient liquid (preferably a large glass of tap water).
In an enlarged prostate, Finasteride is often administered in combination with a so-called “alpha-1-adrenoceptor blockers” (as Tamsulosin): Due to the different mechanisms of a very effective combat symptoms and causes is possible simultaneously
What are the side effects Finasteride?
Often (that is, at one to ten percent of patients) caused Finasteride side effects such as decreased libido and sexual dysfunction. Rare (ie at less than one percent of people) there is distension in the chest. Even more rarely leads to taking breast lump or a liquid secretion from the mammary gland.
In the fetuses Finasteride leads to deformities of the external sexual characteristics. Therefore, are pregnant, or women who could become pregnant should not come into contact with the drug.
What should I watch for while taking Finasteride?
Warnings and Precautions
The active ingredient Finasteride can alter a particular laboratory test which serves to identify a malignancy of the prostate tissue (tumor) is used. The possibility of a tumor must be ruled out prior to treatment by the attending physician.
Very rarely develops during therapy with Finasteride in men breast cancer. It must therefore be ensured regular monitoring of the breast tissue by the physician. If, while you are taking Finasteride to nodular changes, pain or discharge from the breast gland, immediately should a doctor be consulted.
Pregnant women and women who may become pregnant, should not take drugs with Finasteride and the tablets also do not share or mortars.
To date, no clinically relevant interactions with other drugs are known.
Pregnancy and lactation
Finasteride is not intended for use in women.
Men who are taking Finasteride should, during sexual intercourse with pregnant women pay attention to the fact that the woman is not with the sperm comes into contact (for example, by using a condom). The reason: Finasteride is also detectable in semen. Where the active substance for the unborn, may cause abnormalities of the external sexual characteristics.
How to get Finasteride
Finasteride is only available on prescription and thus only available with a prescription from a doctor in pharmacy.
More interesting facts about Finasteride
Until recently, the drug Finasteride was still known as a doping agent. The aim of the athletes to stop taking the banned doping agent testosterone (leads to increased muscle growth and general performance increase) was to mask. Meanwhile, drug testing but so sensitive that in spite of taking Finasteride unnaturally elevated levels of testosterone are detectable. Thus, Finasteride today lost its significance as a doping agent.