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The active ingredient EsOmeprazole is one of the so-called proton pump inhibitors and is used to treat heartburn and stomach acid to regulation. It differs in the mode of action of Omeprazole is not, however, its effectiveness is slightly higher. Here you can read everything you need to EsOmeprazole: action, use and possible side effects

How EsOmeprazole works

EsOmeprazole is taken by mouth and in the intestines solve absorbed into the blood. Via the blood vessels then EsOmeprazole reaches the gastric mucosa, which produces gastric acid: The essential component of stomach acid – hydrochloric acid – is discharged in the form of positively charged particles (protons) and negatively charged particles (chloride ions) of certain mucosal cells in the stomach. The mucosal cells use for the “pumping” of protons across the cell membrane, a particular protein. EsOmeprazole inhibits this protein and thus the proton pump. The active ingredient is thus one of the proton pump inhibitors.

EsOmeprazole can only develop its inhibitory action but, if it has reached the stomach lining and is incident on existing gastric acid – it is activated by

mirror image of Omeprazole

The active ingredient Omeprazole, a proton pump inhibitor also is constructed chemically defined, however, it consists of individual particles as image and mirror image behave towards one another. For comparison: The hands of a man are created equal, only a mirror image. These two different types of a substance is referred to as “enantiomers”. Frequently thereof an effective, less harmful or otherwise advantageous as the second enantiomer.

This was the case of EsOmeprazole, an enantiomer of Omeprazole. The other enantiomer of Omeprazole may be degraded in the body only by a particular enzyme in the liver (namely CYP2C19). About three percent of the population barely has this enzyme but why the called Omeprazole enantiomer would accumulate quickly in the blood after repeated dosing with them.

EsOmeprazole other hand can also be degraded by a second enzyme (CYP3A4), which ensures a reliable elimination. With regard to the effect in the gastric mucosa, the two enantiomers of Omeprazole, however, do not differ.

Up, degradation and excretion of EsOmeprazole

EsOmeprazole achieved about one to two hours after ingestion by mouth his maximum blood levels. It binds to the proton pump in the gastric mucosa and its inhibitory effect unfolded there. Free in the blood circulating drug is completely degraded in the liver by the enzymes mentioned. Approximately one and a half hours after taking EsOmeprazole blood levels has fallen by half.

When is EsOmeprazole used?

The active ingredient EsOmeprazole is used in the following cases:

  • to treat heartburn (GERD – gastroesophageal reflux disease)
  • as gastric protection in the longer term intake of certain painkillers (NSAIDs like aspirin / acetylsalicylic acid)
  • in combination with antibiotics in the treatment of infection with the stomach germ Helicobacter pylori
  • for the treatment of Zollinger-Ellison syndrome, a disease that is associated with an increased acid production in the stomach
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Depending on the underlying disease, the use of EsOmeprazole may short or long term carried out.

How EsOmeprazole is used

The active ingredient EsOmeprazole is taken in the form of enteric-coated tablets or capsules. By gastroresistance the preparations of the active ingredient is released only in the intestine, where it can be absorbed into the blood. This recording is particularly good if the ingestion of the drug takes place on an empty stomach (usually in the morning). Depending on the severity of the disease twenty to forty milligrams of EsOmeprazole per day to be taken.

For patients with swallowing difficulties, there is also an intravenous formulation of EsOmeprazole. Alternatively, with the word “MUPS” (multiple unit pellet system) tablets indicated previously dispersed in water and then drunk or administered via feeding tube.

What are the side effects EsOmeprazole?

When taking EsOmeprazole come from tens to hundreds of persons treated as side effects, bloating, nausea and vomiting at one.

In a hundred to a thousand patients show EsOmeprazole side effects such as fluid retention in the arms and legs, insomnia, dizziness and vertigo, paresthesia, fatigue, dry mouth, increased liver enzymes, and skin reactions such as itching and redness. Moreover, especially in the elderly and long-term treatment, the risk of fractures be increased.

What should be considered when taking EsOmeprazole?

Since EsOmeprazole inhibits the formation of stomach acids, the absorption of other drugs that are taken only as a function of stomach acid, may be changed. The concerns about certain antifungal (ketoconazole, itraconazole) and cancers (erlotinib) – its intake can be reduced by concomitant use of EsOmeprazole

Conversely, to increase the uptake of the heart by means of Digoxin and other drugs by taking EsOmeprazole.

In concurrent use of drugs that are metabolized in the liver by the same enzymes as EsOmeprazole, the degradation of either the proton pump inhibitor, or the other drugs may be affected. As a result, there may be both an increase and a reduction in the blood levels of EsOmeprazole or other active ingredients.

When protease inhibitors for the treatment of HIV (atazanavir, nelfinavir) decrease the blood levels with concurrent use of EsOmeprazole, whereas they are in other protease inhibitors (saquinavir, ritonavir) may increase.

Also, blood levels of Methotrexate (for cancer and rheumatism), Tacrolimus (used to suppress the immune system), diazepam (a sedative) and Phenytoin (anticonvulsant) rise when both EsOmeprazole is taken.

As a precaution, should also be monitored, the combined administration of EsOmeprazole and anticoagulants such as warfarin and Clopidogrel.

Pregnancy and lactation

Taking EsOmeprazole during pregnancy was investigated on studies to Omeprazole. Here there was no side effects. Nevertheless, taking in pregnancy should be ascertained medically and be used with caution.

It is not known whether EsOmeprazole is excreted in human breast milk, the drug in breast-feeding should not be used.

Other information

The use of EsOmeprazole is possible for young people from the age of twelve as well as in elderly patients. In patients with severe hepatic impairment, a lower dose may be required.

How to obtain drugs with EsOmeprazole

Small packs containing a maximum of 14 tablets of 20 milligrams of active ingredient to treat heartburn are excluded since August 2014 in Germany by prescription. In higher doses, larger packs and in products with other applications EsOmeprazole is still only available on prescription.

Since when EsOmeprazole is known?

EsOmeprazole is marketed since 2001 by the pharmaceutical company AstraZeneca. It was introduced shortly before the expiry of patent protection for Omeprazole, also by AstraZeneca.