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Last Updated on March 16, 2024

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The active ingredient Paroxetine is one of the antidepressants on the type of selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, obsessive-compulsive disorder, anxiety disorders, social phobias and post-traumatic stress disorder. They are taken in pill form. Here you can read all about the effect of Paroxetine, side effects and use.

How acts Paroxetine

The neurons in the brain communicate with each other via chemical messengers called neurotransmitters. These are released from one cell and “perceived” by the next on certain docking sites (receptors). Then the messengers from the first cell to be resumed, thus its effect ends.

The neurotransmitter serotonin mediated among other feelings like a good mood, happiness and positive mood. In return, it comes with a relative lack of serotonin, depression and impulsive aggression.

Selective serotonin reuptake inhibitors (SSRIs) such as Paroxetine prevent the resumption of serotonin in the cell of origin. So you make sure that the once distributed serotonin longer acts on the target cell. This allows the serotonin deficiency can be positively influenced – symptoms such as depression and anxiety mend

Pharmacokinetics and metabolism of Paroxetine

The antidepressant is well received after ingestion by mouth (oral intake) in the intestine and then partially metabolized in the liver. The metabolites show no antidepressant effects and are rapidly excreted. Excretion is very individual, about one-third done with the chair, two-thirds of the urine. After one day, approximately half of the absorbed drug is eliminated.

When is Paroxetine used?

The drug Paroxetine is used in depressive disorders, obsessive-compulsive disorder, panic disorder, social anxiety disorder, generalized anxiety disorder and post-traumatic stress disorder.

In general, the treatment is carried out over a longer period, the benefits of therapy should be reviewed regularly.

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How Paroxetine is taken?

In most cases, Paroxetine is administered in pill form. For patients with dysphagia or a feeding tube, there are liquid preparations such as drops or oral suspension.

The treatment is started with a low dose of Paroxetine, which is then gradually increased. Once the desired Paroxetine effect achieved, the appropriate dose for the remainder of therapy is maintained.

The daily dose is taken once daily in the morning and should not exceed 50 to 60 milligrams (depending on the application).

In order to terminate the therapy, will be discussed with the doctor, how to settle the Paroxetine. With abrupt withdrawal strong side effects and withdrawal symptoms may occur, which is why the drug only very slowly (gradually) should be reduced (so-called “tapering off” of therapy).

What are the side effects of Paroxetine?

When taking the antidepressant it very frequently (in more than one in ten patients), nausea and sexual dysfunction.

Often (every tenth to hundredth people) there is Paroxetine side effects such as drowsiness, sleeplessness, tremors, and vomiting are other common side effects.

What should I watch for while taking Paroxetine?

The drug Paroxetine often leads to impulsive and suicidal behavior in children and adolescents. Also, a therapeutic benefit in these age groups is not certain busy. Therefore, the drug should be taken only from the age of 18 years.

In the elderly, it can sometimes lead to a slower excretion, which is why the antidepressant may need to be dosed lower. The same applies to patients with renal or hepatic impairment.

Paroxetine & amp; other substances

Since Paroxetine affects serotonin levels, other active compounds which act on the release of the hormone, have a greater effect. In particular, when taking L-tryptophan (with depression and insomnia), triptans (migraine drugs), tramadol, pethidine and fentanyl (pain killers), Linezolid (antibiotic), MAO inhibitors (antidepressants) and other SSRI caution.

Various agents can inhibit or enhance the degradation of Paroxetine on the liver. These mainly include pimozide (antipsychotic), fosamprenavir and ritonavir (HIV drugs), procyclidine (antiparkinsonian agent), warfarin (anticoagulant) and acetylsalicylic acid (pain killers and anti-coagulant).

Paroxetine & amp; Alcohol

Experts, during treatment with Paroxetine to avoid alcohol. Otherwise, it may lead to an increased alcohol effect to severe nausea and discomfort.

Paroxetine & amp; Pregnancy

Since studies indicate an increased risk of birth defects, no, Paroxetine should be used during pregnancy. In addition, the drug is excreted in human milk, therefore not recommended by an intake during lactation.

How to get medicines with Paroxetine

Paroxetine is available in each strength and pharmaceutical prescription and only in pharmacies.

Since when Paroxetine is known?

The drug was (now GlaxoSmithKline) made in 1992 in the United States by the pharmaceutical company SmithKline Beecham to market. Since 2003, the patent of the original manufacturer’s specifications leaked, numerous generics came with the drug Paroxetine on the market.

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