Last Updated on June 3, 2023
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The active ingredient Losartan (most commonly used in the form of its salt “Losartan potassium”) is one of the most important agents for hypertension. He was admitted in 1995 in the US and is now included in many medications. As a relatively young drug can effectively reduce other drugs blood pressure – and with better tolerability. Pregnant women should take medicines containing Losartan, only after consultation with the doctor. Here you can read everything about Losartan.
How Losartan works
The body has a sophisticated system for regulating blood pressure. If more energy is needed, the blood pressure is automatically increased, however regulated in quiescent phases down.
If this system is disturbed, it can lead to increased blood pressure. Sufferers usually remember nothing about it, and gradually worsened hypertension. Especially the small vessels, such as those found in the eye and in the kidneys are damaged by the constant elevated pressure. Remains a long undetected and untreated, it can draw serious consequences such as loss of vision and renal dysfunction by itself.
In order to avoid such damages, the blood pressure must be normalized. Sometimes to meet weight reduction and increased physical activity and sports. In other cases, but also antihypertensive drugs also need to be taken.
These drugs counts Losartan. As a representative from the group of so-called AT 1inhibitor Losartan blocked the docking of the messenger substance angiotensin II on blood vessel walls. By blocking the vasoconstrictor activity of the neurotransmitter is no longer transmitted. The vessels of the blood system dilate and blood pressure drops slowly. Thus, the blood pressure can be effectively normalized.
Pharmacokinetics and metabolism of Losartan
After recording via the mouth (orally), the active ingredient is only partially absorbed from the intestine into the blood. According to its distribution in the organism it is then metabolized in the liver. Among other things, creates a degradation product that still has a hypotensive effect. Nevertheless, the effect of Losartan only lasts about 12 hours. The degradation products are excreted through the kidneys.
When is Losartan used?
Among the areas of application (indications) of Losartan include:
- cardiac dysfunction (in patients, the so-called ACE inhibitors such as Enalapril can not tolerate)
How Losartan is taken?
The active ingredient is typically applied in the form of tablets. Due to rapid degradation in the body, it may be necessary to take Losartan twice a day. Thus a uniform effect is ensured. Often enough a once daily regimen of.
The usual dose is 12.5 to 100 milligrams per day. Children, adolescents and patients with renal impairment a reduced dose.
What are the side effects of Losartan?
Often, that is, at one to ten percent of those treated, causes side effects such as Losartan, fatigue and circulatory problems.
Occasionally (in less than one percent of people) there is by taking to gastrointestinal discomfort and palpitations.
The side effects can be very limited in a close-knit monitoring of therapy by the doctor.
What should I watch for while taking Losartan?
pregnant in the second and third thirds of pregnancy as well as people with severe hepatic impairment should not take drugs with Losartan.
Due to the concomitant use of Losartan with other drugs may lead to interactions. So the following medications increase the hypotensive action of Losartan:
- Tricyclic antidepressants (such as Imipramine or)
- Baclofen (muscle relaxants)
Certain painkillers (such as) is reduced, the effect of Losartan.
This interaction is especially important in patients with renal dysfunction. In a simultaneous intake may lead to a further deterioration of renal function.
Driving and using machines
Because after taking may occur dizziness and circulatory problems, should pay special attention to the start of treatment to the individual responsiveness. The best then you decide together with your doctor whether you may drive or operate heavy machinery on the road running.
The active ingredient may be used in children from the age of six years. You will receive a reduced dose is adjusted to the body weight.
Pregnancy and lactation
The active ingredient may in the second and third trimester of pregnancy can not be taken because it has had an impact in the past, in some cases, harmful to an unborn child.
In the first trimester of pregnancy and during lactation the drug should only be used according to strict medical benefit-risk assessment. Alternatively, are better proven high blood pressure medicines (antihypertensives) available such as alpha-methyldopa or Metoprolol.
How to get medicines with Losartan
medication Losartan are available by prescription, because hypertension requires periodic visits to the doctor. You get it therefore only with a prescription from a doctor in pharmacy.
Since when Losartan is known?
In 1995, the drug Losartan in the US has been approved as a remedy for high blood pressure. He was the first representative of the so-called AT 1inhibitors. Losartan acts as good a hypertension contrary to the popular ACE inhibitors (Captopril, Enalapril, Ramipril, Lisinopril). These dissolve as common side effect, however cough out, which is not the case with Losartan.
What you should also know about Losartan
Originally paid patients only between five and ten euro copayment for drugs with Losartan. But since July 2014 new contracts between health insurance companies and the pharmaceutical industry apply. More and more patients have since been converted to other drugs because of the co-payment has increased enormously for their medications. This also applies to the AT 1inhibitors, because the health insurance companies see them as no special additional benefits. Therefore, they have the fixed price they pay per pack, extremely reduced. The pharmaceutical industry has its selling price, however, not be adjusted accordingly. The difference from the sales price of drugs with Losartan , the patient has to bear himself.