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Imipramine belongs to the drug group of tricyclic antidepressants: antidepressant drugs with similar chemical structure. It occupies the binding sites for various brain neurotransmitters and thereby alter the influence of these neurotransmitters in brain metabolism. In particular, it blocks transport substances after signal transmission back carrying noradrenaline back into the memory slots. Noradrenaline remains longer at the site, and its effectiveness rises. Imipramine affects mood enhancing, anxiolytic and positively affects frequent sleepwalking or nocturnal enuresis from. The mood effect seems to be also responsible for the successful treatment of eating disorders. For chronic pain the processing of pain signals in the brain is often disturbed. The neurotransmitter serotonin probably plays a major role in the construction of a filter for incoming pain signals. Treatment with Imipramine can potentially replace the constant use of painkillers. The drug must be taken regularly for a long time.