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Last Updated on March 16, 2024

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The active ingredient Lisinopril is one of the most important agents for hypertension. It belongs to the group of medicines called ACE inhibitors and is usually applied in tablet form. Possible side effects include drowsiness, headache and cough. Children, pregnant and nursing mothers should not take medications that contain Lisinopril, only after consultation with the doctor. Here you can read everything about Lisinopril.

How Lisinopril works

The body has a sophisticated system for regulating blood pressure. If more energy is needed, the blood pressure is increased automatically; at rest on the other hand he is down-regulated.

If this system is disturbed, it can lead to increased blood pressure. Sufferers usually remember nothing about it, and gradually worsened hypertension. Especially the small vessels, such as those found in the eye and in the kidney, suffering from constantly elevated pressure. Remains a long undetected, he can draw serious consequences such as loss of vision and renal dysfunction by itself.

In order to avoid such damages, the blood pressure must be normalized. This sometimes can be reached by losing weight and exercising more often antihypertensive drugs must also still be taken.

These drugs counts Lisinopril. As a representative of the group of “ACE inhibitors” Lisinopril reduces the formation of vasoconstrictor mediators (angiotensin II) and enhances the formation of vasodilator mediators (bradykinin). Thus, the blood pressure can be effectively lowered, which also relieves the heart.

Pharmacokinetics and metabolism of Lisinopril

After recording via the mouth (orally), the active ingredient is incompletely absorbed from the intestine into the blood. It is distributed in the body and is eventually excreted unchanged by the kidney.

When is Lisinopril used?

Among the areas of application (indications) of Lisinopril include:

  • high blood pressure (hypertension)
  • heart failure (congestive heart failure)
  • short-term treatment of myocardial infarction

How Lisinopril is used

The active ingredient Lisinopril is usually applied in the form of tablets. The dosage is usually between ten and 80 milligrams – depending on the application and severity of the particular disease. The dose must therefore be determined individually for each patient.

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children, adolescents and patients with renal impairment receive a reduced dose.

The tablets must be taken only once a day, preferably with a large glass of water and always to the same time of day.

What are the side effects Lisinopril?

Often, that is, at one to ten percent of those treated, causes Lisinopril side effects such as drowsiness, gastrointestinal ailments and low blood pressure (hypotension).

More rarely occurs in the course of treating allergic reactions, changes in behavior and circulatory disorders in the end members of the fingers (Raynaud’s syndrome).

What should I watch for while taking Lisinopril?

In patients with diabetes mellitus (diabetes) should medication Lisinopril be used with caution.


drugs with Lisinopril must not be applied if the Subject has a so-called angioedema – caused by allergic reaction swelling in the facial area. The same is true for women in the second or third trimester of pregnancy (trimester). For use in the first trimester of pregnancy, see below.


medication Lisinopril amplify concomitantly the impact of the following:

  • The driving water pills (diuretics)
  • Lithium (used to treat schizophrenia)
  • high blood pressure medicines (such as Metoprolol and Propranolol)
  • remedy for depression (such as)
  • remedy for diabetes (diabetes), such as insulin, glyburide and Metformin

Certain painkillers (non-steroidal anti-inflammatories such as aspirin and) reduce the antihypertensive effect of Lisinopril.

Driving and using machines

Because sometimes can occur as a side effect dizziness or vertigo, patients should pay particular attention to the start of treatment with Lisinopril on the individual response of one’s body to the drug. Then should – be decided whether one must drive or operate heavy machinery on the road active


medication Lisinopril can, if absolutely necessary, be applied even in children.

Pregnancy and lactation

The active ingredient Lisinopril should not be used in early pregnancy and during lactation to treat high blood pressure. Instead are better proven high blood pressure medicines (antihypertensives) available such as alpha-methyldopa or Metoprolol.

How to get medicines with Lisinopril

medication Lisinopril are available by prescription, because the treatment with them require regular doctor visits to monitor the course of therapy. You get it therefore only with a prescription from a doctor in pharmacy.

Since when Lisinopril is known?

The group of medicines called ACE inhibitors, there is only since the 1980s. The first representative of this group was found in the venom of a snake, which puts their victims by the sudden onset of hypotension incapacitated. In order to develop it into a effective drug, the chemical structure of the substance has been continually improved, to today’s representatives of ACE inhibitors such as Lisinopril you came.

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