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Last Updated on March 16, 2024

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The active ingredient Ibuprofen is one of the best known remedies for mild to moderately severe pain, fever and inflammation. He is one of the best-selling drugs to nonprescription pain treatment and is considered safe and well tolerated. In some cases, caused Ibuprofen side effects such as gastrointestinal discomfort. In certain groups of patients such as children and adolescents, the Ibuprofen dosage should be reduced. Here you can read everything about the drug Ibuprofen, effects and side effects.

How Ibuprofen works

The active ingredient Ibuprofen counts as well as pain and involved. As a result, an anti-inflammatory, analgesic and antipyretic effect easily adjusts. This effect lasts for about four to six hours. The drug is metabolized by the liver and is excreted after a half hours via the kidneys in half (half-life).

When is Ibuprofen?

Ibuprofen is used to treat mild and moderate pain, such as in musculoskeletal pain (how and migraines and toothaches. As a single agent or in combination with other active anti-inflammatory painkillers is also used for colds and flu.

Ibuprofen is suitable for short-term self-medication as well as to medically supervised long-term therapy.

How Ibuprofen is used

Ibuprofen is often used in the form of tablets or extended-release tablets. In children is like a flavored juice Ibuprofen or Ibuprofen suppositories, which are picked up very quickly in the bloodstream, resorted. There are also effervescent granules and ampoules (for injection) with this drug.

Especially for athletes and people with musculoskeletal pain (such as arthralgia, myalgia) are (often referred to as Ibuprofen Pain Relief) and Ibuprofen ointment options available that enable a local application of a high dose of active ingredient Ibuprofen gel. The body’s metabolism becomes less charged than when taken orally the active substance. This reduces the risk of side effects.

Ibuprofen dosage

The Ibuprofen dose of each dosage forms varies. There are, for example tablets of 200, 400 or 600 mg of active ingredient. From the dose strength, it depends on how often and in what amount a preparation to be applied and allowed. Exact details can be found in the package insert (leaflet).

What are the side effects of Ibuprofen?

The desired effect of relieving pain, reducing fever and inflammation may be accompanied by side effects – Ibuprofen inhibits the production of the protective mucus layer of the gastrointestinal tract, especially the stomach. This may, inter alia, heartburn, abdominal pain, vomiting, and even the formation of gastrointestinal ulcers trigger. Such gastrointestinal complaints (gastrointestinal complaints) are typical and common side effects of NSAIDs. Other adverse effects of this substance group are, for example, hypersensitivity reactions, hematopoiesis disorders and dysfunction of liver or kidney.

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In order to avoid side effects, NSAIDs should generally be in the lowest dose that has the desired effect, applied. In addition, the application period should be as short as possible.

If a long-term use of anti-inflammatory drug and painkiller necessary, the doctor may prescribe additional medications as gastric protection. In practice, often come to proton pump inhibitor for use.

Ibuprofen overdose

Anyone who takes an overdose of Ibuprofen, must be increased side effects expected (especially gastrointestinal complaints). It can even internal bleeding. In addition, kidneys and liver are severely damaged under certain circumstances.

What should be noted when taking Ibuprofen?

The pain and fever agent should (like other NSAIDs) with the following complaints not be taken:

  • Pre-existing gastric or duodenal ulcers, inflammation of the stomach and intestinal tract, including Crohn’s disease and ulcerative colitis (inflammatory bowel disease)
  • Impaired hepatic or renal function
  • intolerance to other drugs from the group of NSAIDs
  • asthma and other chronic respiratory diseases

Ibuprofen interactions

Who (ASS) is treated for anticoagulation with low dose aspirin, the painkiller should apply with caution – the “blood thinning” effect of ASA may be decreased

Caution is also during simultaneous use of drugs that can be used safely only in a narrow dose range (narrow therapeutic index), and Ibuprofen – effects and side effects of other drugs may increase dramatically. This applies, for example Digoxin (heart medicine), lithium (mental illness) and Phenytoin (epilepsy).

In addition, all NSAIDs the effect of oral diabetes drugs enhance and reduce those of diuretics (diuretics).

Ibuprofen and alcohol

physicians, while the use of Ibuprofen to avoid alcohol. Doing so can cause unpredictable interactions and increased side effects.

Ibuprofen: Pregnancy and lactation

During the first and second trimester of pregnancy Ibuprofen can be temporarily applied. But first consultation should be held with the doctor, as well as in general, any medication should be discussed in pregnancy with the doctor. In the last third of pregnancy all NSAIDs should be avoided.

In lactation, the pain and fever reducer can be used in consultation with the doctor. In studies of women who had taken during lactation Ibuprofen, no side effects were observed in the child. In addition, the pain and fever reducer can also be applied in infants even on doctor’s orders.

How to get medicines with Ibuprofen

The active ingredient Ibuprofen is available over the counter in pharmacies in the form of tablets, orodispersible tablets, soft capsules, beverage granules, juices and suppositories up to a dose of 400 milligrams (for adults).
preparations with Ibuprofen dosage from 400 milligrams and injectable preparations require a prescription.

Since when Ibuprofen is known?

Ibuprofen was developed by a British company in the early 1960s and patented. 1969 came there as a prescription medication for rheumatoid arthritis on the market. About 15 years later-the-counter Ibuprofen preparations in Britain were first available. In Germany in 1989 with 200 milligram tablets, tablets Also with 400 milligrams of Ibuprofen were prescription.

More interesting facts about Ibuprofen

The painkiller is part of numerous preparations for self-medication of headaches and migraines. For this purpose, the active substance is often used as a salt of the body’s amino acid lysine (Ibuprofen lysinate), whereby it is taken up more rapidly. This speeds up the onset of action. In studies, this effect was confirmed. In the self-medication, however, is to note that you can achieve this faster absorption and action only when taking the drug on an empty stomach.

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