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What is Diclofenac?
The active ingredient Diclofenac belongs to the non-steroidal anti-inflammatory drugs (NSAIDs, NSAIDs) and is used for mild to moderate pain. He usually can be found in drugs as sodium salt (Diclofenac sodium). The painkillers came in 1974 on the market, is now included in many drugs and is generally well tolerated. In some cases, however, can cause side effects such as Diclofenac gastrointestinal symptoms (nausea, gastric mucosal damage, etc.) and central nervous system symptoms (headache, fatigue, insomnia, etc.). Here you can read everything about the drug Diclofenac.
Why is this medicine prescribed?
Diclofenac Capsules (Zipsor, Zorvolex) and pills (Cataflam) are utilized to relieve mild to moderate discomfort. Diclofenac extended-release pills (Voltaren XR), pills (Cataflam), and delayed release tablets (available generically) are utilized to relieve pain, swelling, tenderness, and stiffness brought on by osteoarthritis (arthritis brought on by a breakdown of the lining of the joints), and rheumatoid arthritis (arthritis due to swelling of the lining of the joints). Diclofenac extended-release pills and delayed-release pills can also be utilized to deal with ankylosing spondylitis (arthritis that primarily affects the spine). Diclofenac pills (Cataflam) can also be utilized to treat painful menstrual cycle. Diclofenac remedy (Cambia) can be used in the treatment of migraine headaches in adults, but can’t be used to prevent migraines or to deal with different forms of headaches. Diclofenac is in a class of drugs. It works by stopping the creation of the body.
How should this medication be used?
Diclofenac Comes as a pillcomputer, and liquid-filled capsule, a hard gelatin capsule, an extended-release (long-acting) pill, a delayed-release (sparks medicine from the gut) pill, and as packs of powder for solution (to be mixed with water) and take orally. Diclofenac capsules are usually taken 4 times each day and hard gelatin capsules are usually taken three times each day. Daily, Diclofenac pills are taken once, if necessary to control pain, and in rare instances are taken twice per day. Diclofenac pills and tablets are usually taken 3, two, or 4 times every day. Solution is taken to alleviate the pain of migraine headaches. In the event you were advised to take diclofenac on a regular basis, take it at about precisely the exact same period(s) daily. Follow the instructions on your prescription label carefully, and ask your physician or pharmacist to explain. Take diclofenac exactly as directed. Don’t take more or less of it or take it more frequently than prescribed by your physician.
Different The medicine is released by products differently and can’t be used. Take the merchandise and don’t change to another merchandise that is diclofenac unless your doctor says that you should.
Your Physician may Adjust the dose of your medicine during your treatment based upon your reaction to the medication. Speak with your doctor about how you’re feeling during your treatment.
If You’re currently taking The powder for solution, until you choose it you’ll have to combine it. To combine the medicine eliminate 1 packet connected packets. Put 2 to 4 tbsp (1 to 2 oz; 30 to 60 mL) of water in a cup. Insert this packet’s contents and blend well. Drink the whole mixture immediately. Throw away the package in a garbage can that is out of the reach of pets and children.
Other uses for this medication
This medication may be prescribed for other uses; ask your doctor or pharmacist.
Mechanism of action
After including the active substance in the form of Diclofenac sodium or -potassium he is transported to the site of action via the blood. It inhibits the formation of prostaglandins here. Those are growth hormones, which are involved in inflammatory processes of the pain and the development of mediation. By inhibiting prostaglandin therefore Diclofenac has analgesic, anti-inflammatory, antipyretic and anti-rheumatic.
The painkiller is metabolized by the liver and largely excreted through the kidneys. The time until the body has eliminated half of the active substance, is about one to three hours. However, Diclofenac accumulates in tissues with acute inflammatory response and conveys to about six hours after taking its effects on the affected spot.
In high-dose long-term therapy, the prostaglandins that protect the stomach lining and are also responsible for adequate blood flow to the kidneys are permanently not formed and it comes increasingly to side effects.
When is Diclofenac used?
Diclofenac is used primarily for pain and inflammation of musculoskeletal system, for example, muscle, tendon and joint pain. Even for short-term use in migraine and menstrual problems of drug is suitable. In addition, he will be given over the long term in low doses for the treatment of diseases such as arthritis, gout and in pain after surgeries and injuries. Possible side effects from higher doses with long-term use can be prevented or mitigated by the administration of combination products or additional gift of the gastric protective agent misoprostol.
For pain and inflammation of muscles, tendons or joints usually Diclofenac Gel, Diclofenac ointment or Diclofenac Spray is used. These topical dosage forms have the advantage that one just for localized pain reaches a high concentration of active ingredient with them.
However, there are many other embodiments for Diclofenac. For short-term, severe pain like menstrual cramps and migraine pain relievers can be used as drinking tablet (tablet to dissolve in a glass of water), soft capsule or in the form of drops in fast-acting form. For children and patients with swallowing difficulties particularly Diclofenac suppository suitable. Even as an injection solution the active ingredient is available.
Tablets, active substance patches and capsules are often used as a chronic treatment, the active ingredient release delay (Diclofenac Retard capsules). Especially with patches and sustained-release can be good constant drug levels in the blood reach. This can be useful in order to prevent side effects, concomitant use of gastric protective agent misoprostol.
Frequency of use
The frequency of application will depend on the dosage form and the dosage strength. For preparations for taking apply: Non-prescription drugs with Diclofenac should – like other non-prescription pain reliever – without medical advice no longer than three consecutive days and no more than ten days in the month to be taken
Diclofenac Gel and Diclofenac ointment may be applied three to four times per day, a maximum of one to three weeks. A maximum of 16 grams or ointment Diclofenac Gel may be applied per day. Since mid-2013 a Diclofenac Gel is available without a prescription as a “forte” shape. It is twice as strong as the conventional metered Diclofenac Gel and must therefore only be applied twice a day with a maximum amount of 8 grams of gel.
Prescription drug Diclofenac are applied according to the doctor.
What are the side effects of Diclofenac?
Diclofenac side effects occur mainly when taking the drug, rare in its application as a gel, ointment or spray.
Very common (in more than ten percent of users) leads to:
- gastrointestinal bleeding (indicated by a black tarry stool)
Often (at one to ten percent of users) leads to:
- stomach ulcers
- Increase in liver enzymes
In case of Diclofenac side effects (especially in adverse effects in the gastrointestinal tract), a doctor should be informed immediately.
What should I consider when taking Diclofenac?
In principle should not be applied Diclofenac in combination with other pain medications from the class of non-steroidal anti-inflammatories, or if an intolerance to this drug class is. Among the non-steroidal anti-inflammatories other than Diclofenac include, for example, acetylsalicylic acid (ASA), Ibuprofen and Naproxen.
Patients with gastrointestinal ulcers and blood formation disorders should not take Diclofenac. Other contraindications are heart failure (congestive heart failure), ischemic heart disease (coronary artery disease), peripheral arterial disease and vascular disease in the brain (cerebrovascular disease). The reason: Diclofenac increases the risk of formation of blood clots in the arteries
In other cases, the pain reliever should be used with caution and in consultation with a doctor, such as at:
- significant risk factors for cardiovascular events (myocardial infarction, stroke, etc.) such as hypertension, elevated blood lipids (hyperlipidemia), diabetes (diabetes mellitus) and smoking
- chronic inflammatory bowel disease (Crohn’s disease, ulcerative colitis)
- kidney or liver weakness
- Asthma: risk of severe asthma attacks and other consequences
- children and young people under 14 years old
In the last third of pregnancy and during lactation the drug Diclofenac should not be taken.
When co-administered Diclofenac may increase the blood levels of lithium (for mental illness), Digoxin (for heart disease) and Phenytoin (for epilepsy). The blood levels of these drugs should be monitored.
Because of possible interactions is also caution with concomitant use of:
- Diuretics (water pills),
- ACE inhibitors (for high blood pressure, heart failure, etc.)
- hypertension medication
- glucocorticoids (“cortisone”),
- Methotrexate (for rheumatoid arthritis and cancer),
- fluoroquinolones (epilepsy),
- anticoagulants (anticoagulant),
- oral diabetes drugs and
- ciclosporin (after organ transplants, autoimmune diseases).
Who occupies in addition to Diclofenac alcohol burdened his liver in two ways, because the detoxification organ must reduce both substances. An increase in the bleeding tendency is discussed with concurrent use of Diclofenac and alcohol. During treatment should therefore be dispensed with alcohol.
How to get drugs with Diclofenac?
Drugs with Diclofenac may be only available at pharmacies. Certain forms are available over the counter, ie available without prescription, namely topical dosage forms (Diclofenac Gel, ointment, -spray) and single-dose forms (tablets, soft capsules, suppositories) with a maximum of 25 milligrams of active ingredient content. Other dosage forms, however, are only available on prescription.
History of Diclofenac
The active ingredient Diclofenac was systematically developed from older analgesic agents of the class of non-steroidal anti-inflammatories. He was (now Novartis) brought in 1974 by Ciba-Geigy to the market and is now part of many medications.