Last Updated on January 15, 2019
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The active ingredient Meloxicam is a painkiller and anti-inflammatory agent selected from the group of non-steroidal anti-inflammatory drugs (NSAIDs). As with other NSAIDs, it inhibits the production of proinflammatory tissue hormones. But because of its more targeted effect it will have fewer side effects than other NSAIDs such as acetylsalicylic acid (ASA), Ibuprofen or Diclofenac. Here you can read more about Meloxicam.
How Meloxicam works
The active ingredient Meloxicam inhibits the enzyme cyclooxygenase (COX), which is important for the formation of prostaglandins. Those are growth hormones, have various functions. The enzyme COX is available in two subtypes (cyclooxygenase-1 and -2):
The COX-1 is found in many tissues of the human body. She is involved in the formation of prostaglandins, which control primarily endogenous processes such as the formation of stomach acid or blood flow to the kidneys.
In contrast, COX-2 is selectively formed in the inflamed and injured tissues, so there increased prostaglandins are formed as inflammatory messengers. That is, the prostaglandins promote here the inflammation so that the injured tissue is well supplied with blood and the immune system may be reached invading pathogens at an early stage.
NSAIDs inhibit the enzyme COX, where the ultimate goal is the COX-2. But Senior representatives such as acetylsalicylic acid / aspirin act non-selectively, that is, they inhibit both COX-2 and COX-1 – with corresponding side effects. Meloxicam other hand belongs to a group of newer NSAIDs that selectively inhibit only COX-2. Therefore, they have fewer side effects than non-selective NSAIDs. Another advantage is its usually longer duration of action in the body.
Up, reduction and elimination of Meloxicam
After taking Meloxicam over the mouth of the active substance passes into the intestine where it is absorbed into the blood. The maximum blood levels are reached after two to six hours. After the Wirkstiff was metabolized in the liver, it is excreted in approximately equal parts with the stool and urine. Approximately 13 to 25 hours after ingestion of Meloxicam half of its degradation products is excreted.
When is Meloxicam used?
The active ingredient Meloxicam is indicated for:
- short-term treatment of osteoarthritis pain after overload
- Long-term treatment of rheumatoid arthritis (inflammatory disease of the joints) and (ankylosing spondylitis, rheumatic disease of the spine)
How Meloxicam is applied
The pain and inflammation, Meloxicam is taken once daily in tablet form. The intake should always be about the same time, so that the blood levels remain constant. Depending on the severity of the disease and the pain 7.5 to 15 milligrams Meloxicam be taken with a glass of water during a meal. The maximum dose of 15 milligrams per day should not be exceeded.
What are the side effects of Meloxicam?
As typical side effects of Meloxicam occur in about ten percent of those treated indigestion, nausea, vomiting, flatulence and diarrhea. More rarely it comes to headaches.
In a hundred to thousands of patients show up as Meloxicam side effects anemia, allergic reactions (, drowsiness, increased blood pressure, skin rash with flushing and liver dysfunction.
What should be considered when taking Meloxicam?
The steroidal anti-inflammatory drug Meloxicam non-should not be taken with other NSAIDs because NSAIDs-typical side effects may be increased on the digestive tract and kidneys.
Also, the concomitant use of cortisone and anticoagulants (such as warfarin, warfarin) may increase the side effects of Meloxicam and cause bleeding in the gastrointestinal area.
The concomitant use of Meloxicam with blood pressure medications such as ACE inhibitors, diuretics (diuretics) and Sartanen can lead to a deterioration of renal function. Patients should therefore be monitored medically to initiation of therapy. Examples of such agents are:
- ACE inhibitors: Captopril, Ramipril, Enalapril, etc.
- Diuretics: Hydrochlorothiazide (HCT), Furosemide, torasemide etc
- Sartans: Candesartan, eprosartan, Valsartan etc
Meloxicam reduces the blood flow to the kidneys. This can affect the excretion of other active substances. This can be critical for the active substances, in which the blood levels must be set accurately. You can thus accumulate in the body and reach toxic blood levels. This applies, for example Lithium – used to treat mental illness -. And Methotrexate (MTX), which is used in cancer and autoimmune diseases
Pregnant women should not take Meloxicam. Otherwise, serious damage can occur in children, especially in the last trimester of pregnancy. Since the drug is excreted in human milk, nursing mothers should stop breast-feeding better before taking in order not to endanger the child.
Children and adolescents under 18 years of age and older patients (over 65 years) with severe renal impairment should not take Meloxicam. Elderly patients with adequate renal function may take Meloxicam, may, however, the dosage should be adjusted.
How to obtain drugs with Meloxicam
The anti-inflammatory drug Meloxicam requires a prescription in any dosage and package size.
Since when Meloxicam is known?
The active ingredient from the group of oxicams was developed by the pharmaceutical company Boehringer-Ingelheim. In contrast to the other oxicams, which – if at all – in their effect are only poorly selective, Meloxicam is particularly in low dosages, COX-2-selective. Since its approval in Germany in 1996, it was until 2005 under patent protection. Since then, various generics came with the drug Meloxicam on the market.