Last Updated on February 8, 2024
Most online pharmacies provide Meloxicam 7,5 and 15 mg. In case you intend to get Meloxicam online, first study tips about buying drugs online.
Meloxicam is a popular nonsteroidal anti-inflammatory drug (NSAID) used to treat various types of pain and inflammation in the body. While it is available on prescription under various brand names, many people prefer to buy meloxicam over the counter for convenience and cost-effectiveness. However, it is important to note that meloxicam is not available over the counter in the UK or any other country.
In the UK, any medication classified as a prescription-only medicine (POM) can only be obtained with a valid prescription from a qualified medical professional. Meloxicam falls under this category and cannot be purchased over the counter in any pharmacy or online store. Attempting to do so is illegal and can lead to serious health risks, including side effects, drug interactions, and incorrect dosage.
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What is meloxicam?
Meloxicam is a pain reliever and anti-inflammatory agent from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Like other NSAIDs, it inhibits the production of pro-inflammatory tissue hormones. However, because of its more targeted action, it has fewer side effects than other NSAIDs such as acetylsalicylic acid (ASA), ibuprofen, or diclofenac. Here you can read more about Meloxicam.
How does meloxicam works?
Meloxicam inhibits the enzyme cyclooxygenase (COX), which is important for the formation of prostaglandins. These are growth hormones that have various functions. The enzyme COX exists in two subtypes (cyclooxygenase-1 and -2):
COX-1 is found in many tissues of the human body. It is involved in the formation of prostaglandins, which primarily control endogenous processes such as the formation of gastric acid or blood flow to the kidneys.
COX-2, on the other hand, is selectively formed in inflamed and injured tissues, resulting in increased production of prostaglandins as inflammatory messengers. This means that the prostaglandins promote inflammation so that the injured tissue is well supplied with blood and the immune system can reach invading pathogens at an early stage.
NSAIDs inhibit the COX enzyme, with COX-2 being the ultimate target. However, senior representatives such as acetylsalicylic acid / aspirin act non-selectively, i.e. they inhibit both COX-2 and COX-1 – with corresponding side effects. Meloxicam, on the other hand, belongs to a group of newer NSAIDs that selectively inhibit only COX-2. Therefore, they have fewer side effects than non-selective NSAIDs. Another advantage is its usually longer duration of action in the body.
Pharmacokinetics and metabolism of meloxicam
After taking Meloxicam by mouth, the active ingredient passes into the intestines where it is absorbed into the blood. Maximum blood levels are reached after two to six hours. After being metabolized in the liver, the drug is excreted in approximately equal amounts in the stool and urine. Approximately 13 to 25 hours after ingestion of Meloxicam, half of its metabolites are excreted.
When is meloxicam used?
Meloxicam is indicated for:
- short-term treatment of osteoarthritis pain after overload
- long-term treatment of rheumatoid arthritis (inflammatory disease of the joints) and (ankylosing spondylitis, rheumatic disease of the spine)
How meloxicam is taken?
The pain and inflammation, Meloxicam is taken once a day in tablet form. The intake should always be at about the same time so that the blood levels remain constant. Depending on the severity of the disease and the pain, 7.5 to 15 milligrams of Meloxicam are taken with a glass of water during a meal. The maximum dose of 15 milligrams per day should not be exceeded.
What are the side effects of meloxicam?
As typical side effects of Meloxicam occur in about ten percent of those treated indigestion, nausea, vomiting, flatulence and diarrhea. More rarely, headaches occur.
In a hundred to thousands of patients show up as Meloxicam side effects anemia, allergic reactions, drowsiness, increased blood pressure, skin rash with flushing and liver dysfunction.
What should I watch for while taking Meloxicam?
The steroidal anti-inflammatory drug Meloxicam should not be taken with other NSAIDs because NSAIDs-typical side effects on the digestive tract and kidneys may be increased.
Also, the concomitant use of cortisone and anticoagulants (such as warfarin, warfarin) may increase the side effects of Meloxicam and cause bleeding in the gastrointestinal area.
Concomitant use of Meloxicam with blood pressure medications such as ACE inhibitors, diuretics, and sartan may lead to deterioration of kidney function. Patients should therefore be monitored medically prior to initiation of therapy. Examples of such agents are:
- ACE inhibitors: Captopril, Ramipril, Enalapril, etc.
- Diuretics: Hydrochlorothiazide (HCT), Furosemide, torasemide etc
- Sartans: Candesartan, eprosartan, Valsartan etc.
Meloxicam reduces blood flow to the kidneys. This can affect the elimination of other drugs. This can be critical for drugs that require precise blood levels. They may accumulate in the body and reach toxic blood levels. This is true, for example, of lithium – used to treat mental illness. and methotrexate (MTX), which is used to treat cancer and autoimmune diseases.
Pregnant women should not take Meloxicam. Otherwise, serious damage to the baby may occur, especially in the last trimester of pregnancy. Since the drug is excreted in human milk, breast-feeding mothers should stop breast-feeding before taking Meloxicam to avoid endangering the child.
Children and adolescents under 18 years of age and elderly patients (over 65 years) with severe renal impairment should not take Meloxicam. Elderly patients with adequate kidney function can take Meloxicam but the dosage should be adjusted.
How to get medicines with meloxicam
The anti-inflammatory drug Meloxicam requires a prescription in any dosage and package size.
How long has meloxicam been in the market?
The active ingredient from the oxicam group was developed by the pharmaceutical company Boehringer-Ingelheim. In contrast to the other oxicams, which are – if at all – only poorly selective in their effect, Meloxicam is COX-2 selective, especially at low doses.
Through a consolidated marketing authorization, meloxicam was given permission to be used in cattle throughout the European Union in January 1998. In 2006, the first generic meloxicam product received approval.
In the United States, meloxicam was authorised for medicinal use in 2000 after being patented in 1977. Although it was created by Boehringer Ingelheim, the drug is also offered in generic form. With more than 19 million prescriptions written in 2020, it was the 28th most often prescribed drug in the country.
Since its approval in Germany in 1996, it was under patent protection until 2005. Since then, several generic versions of meloxicam have been introduced to the market.