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Last Updated on March 16, 2024

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The active ingredient Olanzapine is one of the most important agents for schizophrenia. It was introduced in 1996 on the German market and is now used frequently. He is generally considered better tolerated than the older antipsychotics, but can cause severe weight gain. Children and pregnant women should take the drug only after consultation with the doctor. Here you can read everything about Olanzapine.

How Olanzapine works

In the brain and spinal cord (central nervous system) ensures the interaction between different neurotransmitters that make you feel balanced and appropriate to certain situations (such as excitement, joy) distributed according to need of nerve cells and later resumed and stored.

This balance of neurotransmitters is common in people who suffer from schizophrenia, disturbed.

The active ingredient Olanzapine belongs to the group of medicines called “atypical antipsychotics”: It blocks certain docking sites (receptors) of serotonin and partly also of dopamine. The effect of chemical messengers can be brought back into balance – schizophrenia symptoms improve. Simultaneously Olanzapine has a slight sedative effect and prevent manias (phased strong drive increase) before.

Pharmacokinetics and metabolism of Olanzapine

After recording via the mouth (orally) the drug is well absorbed from the intestine into the blood. According to its distribution in the body it is then metabolized in the liver. The degradation products are primarily excreted via the kidneys.

When is Olanzapine used?

Among the areas of application (indications) of Olanzapine include:

  • the treatment of manic episodes in schizophrenia
  • the prevention of manic episodes in bipolar disorder

How Olanzapine is taken?

The active ingredient Olanzapine is usually taken in pill form, in acute cases, the drug must be injected directly into the blood. Usually, the daily amount of active ingredient ten milligrams. If necessary, the dose may be increased gradually up to 20 milligrams per day.

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The full effect of Olanzapine unfolds several days to weeks after initiation of treatment.

What are the side effects of Olanzapine?

Very often, that is at more than ten percent of those treated, causes side effects such as Olanzapine and drowsiness.

Often (at one to ten percent of patients) the treatment results in changes in the blood count, and low blood pressure.

What should I watch for while taking Olanzapine?

In the following illnesses the doctor should prior to treatment with Olanzapine balance the individual risk against the benefits and decide on the next steps:

  • dementia
  • Parkinson
  • Diabetes (diabetes)
  • enlargement of the prostate (prostatic hyperplasia)


Patients with narrow-angle glaucoma (eye disease) should not take drugs with Olanzapine.


The Epilepsy agents Carbamazepine may antagonize the effect of Olanzapine, by speeding up the degradation of the active ingredient. has the same effect smoking.

By blocking the breakdown of the following medications increase the Olanzapine-effect:

  • fLuvoxamine (for depression)
  • Ciprofloxacin (antibiotic)

Driving and using machines

As a side effect that can occur when taking Olanzapine drowsiness and dizziness. Therefore, it should particularly be paid to the individual reaction to the drug at the beginning of the treatment. Together with the doctor is then to decide whether an active part in driving or operating heavy machinery is possible.


For the use of Olanzapine in children and adolescents are very few experiences. Treatment should therefore be carried out by highly experienced physicians when the individual benefit compared with the risk clearly outweighs.

Pregnancy and lactation

According to experts, should be used during pregnancy instead of Olanzapine better proven alternatives (Risperidone, Quetiapine). If a pregnant woman, however, set well with the active ingredient (good efficacy with good tolerability), he must be taken. It may shortly after birth cause adjustment disorders of the newborn, which is why medical care must be ensured.

During lactation have been detected no problems in the infant by maternal treatment with Olanzapine. Therefore, taking this drug during lactation is considered “acceptable”.

How to get medicines with Olanzapine

medication Olanzapine are only available on prescription, since the success of treatment should be regularly checked by a doctor. You get the drugs therefore only with a prescription from a doctor in pharmacy.

Since when Olanzapine is known?

Olanzapine is a relatively “young” drug. It was developed from the so-called “classic neuroleptics”, ie agents for mental disorders, and approved in 1996 in Germany. As a representative of the group of “atypical antipsychotics” second generation has Olanzapine fewer side effects, but can cause severe weight gain.

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