Last Updated on June 3, 2023
Ramipril is a medication used to treat high blood pressure and heart failure. It works by relaxing blood vessels, making it easier for the heart to pump blood. In the United Kingdom, ramipril is a prescription-only medication, meaning it cannot be purchased over the counter. However, there are some online pharmacies that allow patients to obtain a prescription and purchase ramipril online.
It is important to note that obtaining medication online can come with risks, such as counterfeit or unsafe drugs. It is important to research online pharmacies thoroughly and ensure they are licensed and reputable before making a purchase. Patients should also consult with their healthcare provider before starting any new medication, including ramipril.
In addition to online options, patients may be able to obtain ramipril through their local pharmacy with a valid prescription from their healthcare provider. It is always recommended to speak with a pharmacist or healthcare provider for guidance on the best ways to obtain and take medications safely and effectively.
Ask your pharmacist any questions you have relating to this medication, especially if it’s new to you. Buy Ramipril online in the very best affordable cost from BuyOvertheCounterUK.net and get your Ramipril tablets shipped at your doorstep in time.
What is ramipril?
Ramipril is a drug used to treat high blood pressure and heart failure. It was patented in the USA in 1991 by Aventis (now Sanofi). Since the patent expired, it has been included in many medicines. Ramipril is used either alone or in combination with other drugs. Children and pregnant women should not take the drug, or should only take it after consulting a doctor, as a side effect of Ramipril may include growth retardation.
How does ramipril works?
Ramipril is an ACE inhibitor. ACE (angiotensin converting enzyme) is a substance involved in a complex system that regulates blood pressure. When ACE is inhibited, the body produces less of the hormone angiotensin II. This constricts blood vessels and keeps blood pressure high. It also causes the kidneys to excrete less water – keeping blood pressure high.
After taking ramipril orally, the concentration of the drug in the blood rises to its maximum level after about an hour. However, the ACE inhibitor ramipril (ramiprilate) only needs to be converted into its active form in the body. In this form, the drug reaches its maximum concentration in the blood after two to four hours and then declines. Ramiprilat is excreted by the kidneys – after about 7 to 13 hours, half of the active ingredient has left the body. With regular use, the drug level reaches a steady state after about four days.
When is Ramipril used?
Ramipril is mainly used to treat high blood pressure (hypertension). It is also used to treat heart failure (reduced cardiac output), certain types of kidney disease and to prevent and treat heart attacks. This medicine is usually used on a long-term basis.
How ramipril is taken?
The active substance ramipril is only available as a finished product in tablet form in Germany. Treatment usually starts with small daily doses of 1.25 to 2.5 milligrams once a day. The dose is gradually increased over several weeks to the maintenance dose set by the doctor. Manufacturers offer tablets with 2.5, 5 and 10 milligrams of active ingredient, so that the individual dose can be well adjusted. As it takes about four days to reach a constant level of medication, it is important to take the tablets regularly at the same time of the day, regardless of meals.
If the blood pressure cannot be adequately controlled with ramipril alone, the guideline for the treatment of hypertension recommends a combination with a diuretic (water purifier) and a calcium channel blocker. When treatment with Ramipril is completed, you must not – as with other drugs – with an increased rise in blood pressure (rebound effect). In consultation with the doctor, Ramipril can therefore be allowed to settle without you dose it tapered off.
What are the side effects of ramipril?
If treatment is started at too high a dose, ramipril may cause an unexpectedly large drop in blood pressure. This is why the drug is given gradually. Like all drugs, Ramipril has side effects. Ramipril causes the following common (in one to ten percent of patients) complaints:
- muscle spasms and pain
- increased blood potassium levels
What should I watch for while taking ramipril?
Patients with impaired renal function should take a lower dose of ramipril as they excrete the drug more slowly. Patients with impaired liver function take longer to convert to the active form, so the onset of action may be delayed.
The therapeutic benefits of ramipril are seen from two years of age into old age. However, the potential for growth retardation must be taken into account when treating children. Ramipril should not be taken during pregnancy or while breast-feeding.
Because of the side effects, you need to be especially careful when taking ramipril if you are taking the same drugs that:
- the potassium concentration in the blood change (eg potassium effervescent, heparin, potassium-sparing diuretics).
- lower blood pressure (risk of excessive blood pressure drop).
- can also change the number of blood cells (e.g. allopurinol, immunosuppressants, corticosteroids, cytostatics).
- contains the mood stabiliser lithium.
In addition, Ramipril may increase the hypoglycaemic effect of insulin and other oral antidiabetic agents. Concomitant use of NSAIDs (e.g. aspirin, diclofenac) reduces the effect of Ramipril. Patients taking the drug should avoid if pain and fever on drugs with the active ingredient paracetamol.
How do I get ramipril?
Because ramipril affects important bodily functions, the active ingredient in each dose is only available on prescription; it can only be obtained from a pharmacy.
How long has Ramipril been known for?
Ramipril was brought to market in 1991 by Aventis (now Sanofi), which filed for a US patent and successfully completed clinical trials. After 16 years, the patent was overturned prematurely in a lawsuit, opening up the market to other manufacturers. Since then, ramipril has been marketed as a generic by various manufacturers. The original product is still on the market.
The name “second-generation ACE inhibitor” comes from the fact that Ramipril is a further development of Captopril, which is still in use today. It is derived from a substance found in the venom of Bothrops jararaca, which was developed in the USA in 1975 and approved in 1981. However, this drug is very sensitive to air and moisture, and can cause rashes and taste disturbances, so improvements were needed. More than ten other ACE inhibitors have been developed and are used worldwide.
More interesting facts about ramipril
The most negative symptoms experienced during treatment with ramipril are related to the lowering of blood pressure. Patients are usually so used to having high blood pressure that they experience discomfort when their blood pressure returns to normal. However, this and most of the potential side effects of ramipril improve after a few days or weeks of treatment.
The coughing mentioned in ramipril side effects may also occur several weeks after starting treatment with ramipril. In this case, ramipril is usually replaced by an angiotensin II receptor blocker (from the “sartan” group).