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Last Updated on March 16, 2024

Most online pharmacies offer Paracetamol 500 mg. First read tips about purchasing drugs online in case you want to purchase paracetamol online.


Paracetamol, commonly known by its brand name Panadol, is a widely used medication for pain relief and fever reduction. It belongs to the class of analgesics and antipyretics and is considered safe for over-the-counter (OTC) use. If you’re in the UK and wondering where to buy paracetamol 500 mg over the counter, this article will guide you through the various options available.

Paracetamol is a popular painkiller that can be purchased over the counter without a prescription in the UK. It is widely used to treat mild to moderate pain, such as headaches, toothaches, and muscle pains. It can also lower fever and reduce symptoms of cold and flu.

You can find paracetamol in most pharmacies, supermarkets, and convenience stores in the UK. It is sold under various brand names, including Panadol, Tylenol, and Calpol. Paracetamol is available in different forms, such as tablets, capsules, effervescent tablets, and syrup. The recommended dosage of paracetamol for adults is usually 500-1000mg every 4-6 hours, depending on the severity of the pain.

Availability of paracetamol in the UK

In the United Kingdom, regulations govern the sale of paracetamol to ensure its safe and responsible use. While paracetamol can be found in different places, pharmacies and supermarkets are the primary sources where you can purchase it without a prescription.

Where to buy paracetamol (Panadol) 500 mg over the counter

A. Local Pharmacies

Local pharmacies are a reliable option for buying paracetamol. They offer the advantage of professional guidance and advice from pharmacists who can assist you in choosing the right product and provide any necessary information. To find a nearby pharmacy, you can utilize online directories or ask for recommendations from friends, family, or healthcare professionals.

B. Supermarkets and Grocery Stores

Supermarkets and grocery stores are known for their convenience and accessibility. Many of these establishments have dedicated sections for medications, including paracetamol. Popular supermarket chains such as Tesco, Asda, and Sainsbury’s often stock paracetamol in different strengths, including the 500 mg variant.

C. Online Retailers and Pharmacies

The internet has made buying medications more convenient than ever. Online retailers and pharmacies offer a wide range of options for purchasing paracetamol. The benefits of buying online include the ability to compare prices, read customer reviews, and have the product delivered to your doorstep. Trusted online platforms such as Boots, LloydsPharmacy, and Pharmacy2U are well-established and provide genuine paracetamol products.

Considerations when buying paracetamol (Panadol) 500 mg over the counter

A. Price Comparison

When buying paracetamol, it’s wise to compare prices to ensure you’re getting the best deal. Factors such as brand, pack size, and retailer can influence the price. Websites like PriceRunner and MySupermarket allow you to compare prices from multiple retailers, helping you make an informed decision.

B. Quality and Authenticity

To ensure the quality and authenticity of the paracetamol you purchase, it’s essential to be cautious. Stick to reputable pharmacies and verified online retailers. Look for official certification or verification seals on websites, indicating their commitment to selling genuine medications.


In the UK, paracetamol (Panadol) 500 mg can be purchased over the counter from various sources. Local pharmacies offer professional guidance, while supermarkets provide convenience. Online retailers and pharmacies offer the advantage of price comparison and home delivery. When buying paracetamol, it’s important to compare prices, consider quality and authenticity, and make an informed decision that suits your needs.

Buy paracetamol OTC online in the best affordable cost from BuyOvertheCounterUK.net and get your Paracetamol pills sent at your doorstep in time.

What is paracetamol?

Paracetamol is one of the most important medicines for pain and fever. It was developed in the USA and Germany and is now found in many medicines. Non-opioid analgesics (painkillers) are generally well tolerated. After ibuprofen, paracetamol preparations are the best-selling non-prescription painkillers (prescription packages contain a maximum of ten grams of paracetamol). Pregnancy and breast-feeding are not contraindications. If the dose is reduced, the pain and fever reliever can be used at any age. Read all about paracetamol’s effects, side effects and uses.

How does paracetamol works?

The exact mechanism of the analgesic and antipyretic effect is still unknown. However, scientific studies have shown that there are several potentially reinforcing effects on the body that explain the analgesic and antipyretic effects.

In contrast, the active ingredients used to reduce pain and fever and to mediate pain also play a role. Non-acidic, non-opioid analgesics such as paracetamol have a poor anti-inflammatory effect but a good antipyretic effect.

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Paracetamol also affects the endocannabinoid system, which mediates sedative and analgesic effects, and the serotonin system. Serotonin is a neurotransmitter of the nervous system that fulfils many functions. Among other things, serotonin acts on the cardiovascular system, blood clotting and the gastrointestinal tract, and plays an important role in the brain as the ‘happiness hormone’.

Current research is investigating other mechanisms of action of the analgesic and antipyretic.

The maximum concentration in the blood is reached after 30 to 60 minutes with oral administration and after three to four hours with rectal administration (suppositories). The time taken for the drug to be metabolised and excreted by the liver is one to four hours (half-life). Excretion of the active ingredient is inactivated by the kidneys.

When is paracetamol used?

Paracetamol is used for pain and fever, sometimes in combination with other painkillers (such as acetylsalicylic acid = ASA or codeine).

It is usually used for a short time. In certain cases, however, the doctor may prescribe long-term use.

How paracetamol is taken?

For occasional use to relieve minor pain, as the drug is mainly used in tablet form.

Suppositories with paracetamol are particularly suitable for use in children, babies and young children. These are usually easy to use, whereas tablets are often regurgitated by children. In addition, babies and young children are often unable to swallow a tablet with a drink of water – they often choke on them. There are special low-dose paracetamol products for each age group, sometimes according to body weight.

Paracetamol is used to treat colds and flu, mainly because of its fever-reducing properties.

Doctors sometimes give it to their patients as a syringe (injection).

Combination products such as paracetamol plus aspirin, paracetamol plus codeine or the triple combination of paracetamol, aspirin and caffeine (for treating tension headaches and simple migraines) have a better analgesic effect than the individual drugs.

What are the side effects of paracetamol?

Side effects of paracetamol are relatively rare and are usually due to underlying medical conditions.

Paradoxically, low-dose, long-term use of paracetamol can cause headache (“analgesic headache”). It must then be stopped.

High-dose, long-term use and single overdoses of paracetamol can cause liver damage. The liver can no longer fulfil its role as a detoxifying organ – this is known as paracetamol poisoning, with the typical signs of liver failure. Paracetamol overdose is defined as a single dose of six grams or more.

What should I watch for while taking paracetamol?

This analgesic and antipyretic should not be used in cases of severe liver or kidney damage, a certain enzyme deficiency (glucose-6-phosphate dehydrogenase deficiency) or excessive alcohol consumption (alcoholism). The same applies to hypersensitivity (allergy) to the active substance.

In young patients (children), pregnant and breastfeeding women, there is little concern about short-term, low-dose use. A doctor or pharmacist should be consulted for advice on use and dosage.

Paracetamol and alcohol

Because the active ingredient in paracetamol is metabolised by the liver in the same way as alcohol, alcoholics and people with a high alcohol consumption experience a double burden on the detoxification organ, which cannot always be compensated. In these patients, the analgesic may be a trigger. In general, alcohol should be avoided when taking paracetamol.

How to get medicines with acetaminophen

In the UK, the painkiller is available without a prescription in pharmacies up to a total of ten grams per pack (tablets). Paracetamol suppositories are not affected by this rule because the active ingredient is absorbed more slowly.

Higher-dose tablets and injectable solutions require a prescription.

How long has paracetamol been on the market?

Substances related to paracetamol have been studied since 1886 (acetanilide) for their analgesic and antipyretic properties. Based on the work of US chemist Harmon Northrop Morse at Johns Hopkins University in 1877, the substance paracetamol was first identified. The optimisation of the active ingredient of acetanilide over phenacetin to paracetamol was achieved through targeted development of the molecular structure. In fact, paracetamol and phenacetin were first clinically tested by the German physician Joseph von Mering in 1887. However, phenacetin was initially found to be superior, so paracetamol was initially forgotten. In 1947, David Lester and Leon Greenberg were able to show that phenacetin was metabolised to paracetamol and was just as effective.

Paracetamol was first marketed in the United States in 1953 by Sterling-Winthrop Co. (acquired by Bayer) as a direct competitor to aspirin, one of the few drugs available at the time for minor pain.


1. Is paracetamol safe to use without a prescription?
– Yes, paracetamol is generally safe for OTC use when taken as directed.

2. Can I buy paracetamol in bulk?
– The sale of paracetamol is usually limited to a certain quantity per person to prevent misuse.

3. Are there any age restrictions for purchasing paracetamol?
– While there are no specific age restrictions, it’s important to follow the recommended dosage for different age groups.

4. Can I return paracetamol if I change my mind?
– Due to safety regulations, most pharmacies and retailers do not accept returns on medications.

5. Are there any alternatives to paracetamol for pain relief?
– Yes, there are alternative pain relievers such as ibuprofen and aspirin, but it’s best to consult a healthcare professional for guidance.