Last Updated on May 23, 2023
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Bisoprolol belongs to the group of beta-receptor blockers (briefly called beta-blockers). These drugs reduce the human heart, the effect of the hormone adrenaline, making them suitable for the treatment of cardiovascular diseases such as high blood pressure (hypertension), heart rate (tachycardia), heart failure (congestive heart failure) and heart Enge (angina). Everything you need to know the effect of Bisoprolol, side effects and application notes is summarized below.
How Bisoprolol works
The hormone adrenaline and the neurotransmitter (neurotransmitters) norepinephrine effect by docking to the so-called beta receptors on the heart an increase in activity of the heart muscle – myocardial contractile force and heart rate increase, the threshold is lowered at heart. Overall, this means that the pumping of the heart and blood pressure increase. The beta-blocker Bisoprolol now occupied these receptors, so that adrenaline can no longer dock. The result is a weakening of the adrenaline effect: The blood pressure drops, the energy consumption of the heart, together with the oxygen consumption decreases. The total cardiac work is economized, the heart muscle relieved.
When is Bisoprolol applied?
The Bisoprolol comes at the most common cardiovascular diseases are used. These mainly include and chronic heart failure.
Also used (though without official approval, ie in the “off-label use”) in migraine, and preventive (preventive) in bleeding esophageal varices by (Speisröhrenvarizen).
How Bisoprolol is taken?
The beta-blocker is usually administered in the form of its salt as Bisoprolol fumarate in the form of tablets or film-coated tablets. He is both a monopreparation as a combination with a diuretic (medication wasserausschwemmendes – Hydrochlorothiazide). Many heart patients suffer namely water in the body (edema), which can be flushed out using diuretics.
The doctor sets individually, in which dosage form and dosage of beta-blockers in individual cases is most advantageous. The dosage depends primarily on the type and severity of the disease.
What are the side effects Bisoprolol?
The most common side effects are Bisoprolol circulatory disorders, headaches, low blood pressure and greatly slow heartbeat (bradycardia). In addition, Bisoprolol can cause cardiac arrhythmia, dizziness, emerging or worsening psoriasis (psoriasis), cause a spasm of the muscles of the airways (bronchospasm) and sleep disorders. In rare cases, caused the Bisoprolol active hallucinations, mood swings and erectile dysfunction. For existing vascular disease deafness application and a cold sensation in the arms and legs can cause. In patients with diabetes mellitus the drug may mask occurring blood sugar (hypoglycaemia).
When should you not take Bisoprolol?
is contraindicated taking Bisoprolol in bronchial asthma, obstructive lung disease (lung disease with narrowed airways), all slow forms of arrhythmia, low blood pressure, vascular disease in an advanced stage and acidification (acidosis) of the blood. Patients being treated with monoamine oxidase (MAO) inhibitors (eg against depression), the beta-blockers should not take too. The same applies to patients with pheochromocytoma, a usually benign tumor of the adrenal gland.
An allergy or hypersensitivity to beta-blockers or against other components of the drug should be excluded before the start of therapy.
caution in combination with other centrally antihypertensive drugs (such as Clonidine), calcium channel blockers (such as Nifedipine) and drugs that use in cardiac arrhythmias (such as lidocaine, Amiodarone) found.
During pregnancy should be a strict risk-benefit assessment by the physician before starting treatment, as Bisoprolol may influence the blood flow to the placenta and the developing fetus. Careful monitoring of blood flow to the uterus and placenta to take place in Bisoprolol-taking in any case. In addition, other therapeutic options should be considered.
Whether Bisoprolol is excreted in human breast milk is not known. If ingestion during lactation is absolutely necessary, should first be stopped.
In elderly patients, Bisoprolol dosage should be kept as low as possible; in children is no experience before.
Alcohol may increase the hypotensive effect of Bisoprolol.
The dose of Bisoprolol should first be set low and increased in controlled course if necessary. If you want to settle Bisoprolol, the active ingredient should be back down slowly dosed by the physician. Abrupt discontinuation may namely dangerous blood pressure spikes trigger (so-called “rebound effect”).
How to obtain medicines with Bisoprolol
medicines with Bisoprolol are available by prescription and can be purchased only on presentation of a doctor’s prescription in the pharmacy.
More interesting facts about Bisoprolol
Bisoprolol after Metoprolol in Germany the most frequently prescribed beta-blockers. This drug class is generally very often prescribed by doctors, because they very effective and the diseases they treat (such as hypertension) are widespread in the population.