Last Updated on March 16, 2024
Roxithromycin is an antibiotic that is commonly prescribed to patients suffering from respiratory tract infections, skin and soft tissue infections, and certain types of sexually transmitted infections. Although it is mainly available through prescription, there are instances when it may be necessary to obtain roxithromycin over the counter in the UK.
However, it is important to note that obtaining this medication without a doctor’s prescription is illegal and can have serious consequences. In addition, self-diagnosis and treatment can lead to incorrect dosage and prolonged illness. Therefore, it is recommended to always consult with a medical professional before taking any medication, including roxithromycin.
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What is roxithromycin?
Roxithromycin is a macrolide antibiotic. It is a further development of the drug erythromycin, which is also still used as an antibiotic. Here you will learn all you need to know about the action and use of Roxithromycin, including side effects and interactions.
How dies roxithromycin works?
Like animal and human cells, bacterial cells have a genome (DNA) that serves as the blueprint for the proteins that perform many functions in the cell. Macrolide antibiotics such as Roxithromycin inhibit ribosomes, the complexes in the cell where DNA is translated into proteins. Bacterial growth and proliferation are inhibited.
Since the ribosomes of bacteria and humans differ greatly, Roxithromycin can be precisely off bacterial ribosome. In human cells the antibiotic has relatively few (minor) opposite effects.
Pharmacokinetics and metabolism of roxithromycin
After taking roxithromycin, two-thirds of the antibiotic is rapidly absorbed through the intestines into the bloodstream, where it reaches peak levels within two hours. The antibiotic is particularly well absorbed through the lungs, skin, and urinary tract. Roxithromycin also accumulates in immune cells that actively travel through the bloodstream to the site of bacterial infection.
Roxithromycin is partially excreted unchanged and partially metabolized in the liver. Roxithromycin is mainly excreted in the feces through the bile. Approximately twelve hours after dosing, half of the drug has left the body.
When is roxithromycin used?
Roxithromycin is used to treat bacterial infections such as:
- bacterial lung infections
- whooping
- infection of the bronchi
- bacterial
- bacterial infection of the tonsils and throat
- skin and soft tissue infections
- urinary tract infections
Taking roxithromycin is by definition temporary and directed by the doctor. Even if the symptoms return earlier, the therapy must be continued until the end. Otherwise, the infection may return.
How roxithromycin is used?
The antibiotic Roxithromycin is taken in pill form. The amount of active ingredient and the duration of therapy depend on the type and severity of the infection, the patient’s condition, and the susceptibility of the pathogen. A common dose is 150 milligrams of roxithromycin twice a day, about twelve hours before meals, for a total daily dose of up to 300 milligrams. Children under 40 kg body weight and patients with liver damage receive a reduced dosage. Treatment usually lasts from five days to two weeks.
What are the side effects roxithromycin?
While taking Roxithromycin, side effects such as indigestion, skin and mucous membrane reactions with redness, swelling and itching may occur in tens to hundreds of patients.
In hundreds to thousands of patients, there is an increase in white blood cell count, allergic reactions and skin rash with itching.
In rare cases, a so-called superinfection with yeast (Candida) on the buccal or vaginal mucosa as well as the “good” bacteria are killed by roxithromycin – the fungus can then spread easily.
What should I watch for while taking roxithromycin?
Roxithromycin, like other macrolide antibiotics, inhibits drug-degrading enzymes in the liver (cytochrome P450 3A4). In addition, used drugs that are metabolized by this pathway may be metabolized only slowly or not at all. Their concentration in the body can then rise to toxic levels. This is the case, for example, with the ergot alkaloids ergotamine and dihydroergotamine (used in migraine medications, etc.), pimozide (used to treat psychosis and delusions), and the allergy medication astemizole.
Roxithromycin affects the heart rhythm by creating a so-called QT interval prolongation. Concomitant administration of other agents that also have this feature may lead to serious cardiac arrhythmias. Such drugs include antidepressants (citalopram, amitriptyline, imipramine), opioid analgesics (methadone), antipsychotics and anti-schizophrenics (chlorpromazine, perphenazine, zuclopenthixol), antibacterial (moxifloxacin), viral (telaprevir) and fungal infections (fluconazole, pentamidine) and even drugs for irregular heartbeat (quinidine, procainamide, amiodarone).
The active ingredient Roxithromycin increases the absorption of the cardiac drug digoxin, which may increase its side effects. Therefore, serum levels of digoxin (and other cardiac glycosides) should be monitored during concomitant therapy. The situation is similar with the asthma drug theophylline and the Parkinson’s drug bromocriptine.
Under treatment with roxithromycin, statins (lipid-lowering agents) such as atorvastatin, pravastatin, simvastatin, and rosuvastatin are inhibited in their degradation. They can accumulate in the body and lead to statin-typical side effects such as muscle pain and breakdown of muscle tissue (rhabdomyolysis), followed by kidney failure.
During pregnancy, roxithromycin should be used only after a thorough risk-benefit assessment, although animal studies have shown no harmful effects on the fetus.
In lactation, the antibiotic should not be used or discontinued before the start. The reason may interfere with the intestinal flora of the infant under construction Roxithromycin sensitive.
Elderly patients and children over 40 kg of body weight can be treated with Roxithromycin. Patients with hepatic impairment should be treated with caution and in reduced dosage.
How to get roxithromycin
The antibiotic roxithromycin requires a prescription at the pharmacy to buy.
How long has roxithromycin been on market?
Roxithromycin was released in 1987 by the pharmaceutical company Hoechst AG and represents a systematic development of the antibiotic erythromycin. Thanks to chemical changes, roxithromycin has fewer interactions, has a broader spectrum of bacteria, is less sensitive to stomach acid and thus can be better than tablet. Meanwhile, the patent protection has expired and there are numerous generics with the active ingredient Roxithromycin.
