Last Updated on March 16, 2024

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Cefuroxime

Cefuroxime is an antibiotic that kills bacteria and is used to treat infections. The drug was originally derived from the fungus Cephalosporium acremoniumand belongs to the group of medicines called cephalosporin antibiotics. Cefuroxime is used in the case of the respiratory, urinary infections as well as failure of antibiotic treatment with penicillins. Here you can read everything about Cefuroxime.

How Cefuroxime works

Cefuroxime irrevocably inhibits a particular enzyme in bacteria which require this for the structure of the cell wall. As a consequence, the cell wall is damaged so that water can flow into the bacterial cell. This swells the cell and eventually disintegrates. Cefuroxime has therefore a bactericidal (bactericidal) effect.

Pharmacokinetics and metabolism of Cefuroxime

Cefuroxime may be administered by mouth and is then absorbed from the gastrointestinal tract into the body. A direct administration into a venous blood vessel is also possible.

The active ingredient is not degraded, but resigned in antibacterial active form quickly and for the most part via the kidneys from the body.

When is Cefuroxime applied?

The fields of application (indications) of Cefuroxime are:

• respiratory infections, the urinary and genital area and the ear, nose and throat area, the bone, skin and soft tissue infections
• (sepsis)
• (gonorrhea)
• Lyme Disease

How Cefuroxime is taken?

Cefuroxime tablets are taken immediately after eating a large meal. They should not be chewed or divided. Thus, the effectiveness of the antibiotic is improved.

For a Cefuroxime dry juice a ready for use suspension must be prepared prior to first use. These cold, previously boiled water is added to below the mounted on the bottle label. The bottle is sealed and shaken well. Once the foam has completely settled, it is filled exactly up to the mark. The reconstituted suspension should be shaken well before each use. The suspension is metered by volume and taken immediately after eating a large meal.

In order to maintain the drug concentration in the body sufficiently high intake of Cefuroxime should be done regularly. Has the doctor prescribed twice daily administration, the antibiotic should be taken if possible in the 12-hour distance.

The application period depends on the type and severity of the disease and is therefore determined by the physician. The therapy must not be interrupted prematurely, because otherwise the pathogens are not completely killed and the infection may recur. The exciting possibility to a resistance to the drug develop and then speak no longer respond to treatment with the antibiotic to.

Cefuroxime should not be used if a hypersensitivity to a cephalosporin antibiotic or a beta-lactam antibiotic (penicillins, carbapenems, monobactams) there.

In patients with pre-existing renal Cefuroxime is excreted slows. The dosage should therefore be adjusted by the physician accordingly so that there is no accumulation of the active substance in the body.

What are the side effects Cefuroxime?

The most common side effects are Cefuroxime allergic reactions that take place primarily on the skin. With one to ten percent of patients experience skin rash, itching and difficulty breathing and the way to circulatory collapse coming. Allergic reactions may occur following treatment immediately or within days to weeks and are independent of the amount of drug ingested. At the first signs of an allergic reaction, the treatment is interrupted immediately and the doctor should be consulted.

With one to ten percent of patients, and dizziness, as well as fungal infections occur.

When administration of Cefuroxime by mouth occurs in up to one percent of patients to gastrointestinal disturbances such as nausea, vomiting, anorexia, abdominal pain and diarrhea.

Cefuroxime, the results of laboratory tests influence: In blood tests there may be an increase of liver enzymes and a particular type of white blood cells (eosinophilia) come. In addition, the antibiotic to a false positive Coombs test and an incorrect determination of glucose in urine lead. Patients should inform the doctor about taking of Cefuroxime before laboratory tests.

Pregnancy and lactation

Cefuroxime is generally suitable for the use during pregnancy and lactation. In the first three months of pregnancy a strict balance between benefit and risk by the physician is in advance but necessary. In lactation impairment of the intestinal flora of breast-fed child is possible because Cefuroxime is excreted in human breast milk. Moreover, it may lead to a sensitization of the infant, so that a subsequent contact of the child with Cefuroxime may trigger an allergic reaction.

Interaction

Cefuroxime and the following active substances should not be taken simultaneously, since the probability of kidney damage is increased:

• aminoglycoside antibiotics such as amikacin, gentamicin, netilmicin and tobramycin
• diuretic drugs that act on harnbildenden system of the kidneys, such as Furosemide and torasemide

A concomitant use of probenecid inhibits the excretion of the antibiotic. The Cefuroxime dose should therefore be adjusted by the doctor so that there will be no increased concentration of drug in the blood.

remedy for excess stomach acid (antacids) may decrease the effectiveness of Cefuroxime. They should therefore be taken at a distance of two hours to the antibiotic.

Cefuroxime may decrease the effectiveness of birth control pills. During and for several days after the treatment with Cefuroxime therefore should be additionally mechanically prevented (as with condoms).

How to get Cefuroxime

preparations with Cefuroxime are available by prescription and is available by prescription in pharmacies.

Since when Cefuroxime is known?

Cefuroxime belongs to the group of cephalosporins. The oldest member of this group is the cephalosporin obtained by Guy GF Newton and Edward Penley Abraham in 1955 from the fungus Cephalosporium acremoniumin pure form. In the following years many more potent derivatives of cephalosporin were prepared which came onto the market from the mid-1960s.

What you should also know about Cefuroxime

Since the natural bacterial colonization of the intestine is altered by antibiotic activity of Cefuroxims, may cause diarrhea. Preventive or the subsequent reconstruction of the intestinal flora may therefore also products with special drug-yeast (such as Saccharomyces boulardii) can be taken. With the capture can be already started during treatment with Cefuroxime.