Last Updated on June 3, 2023
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Clindamycin inhibits the growth and multiplication of bacteria and is used to treat infections caused by staphylococci and anaerobes (bacteria that grow in oxygen-free environment) used. The active substance is produced synthetically and semi is one of the so-called lincosamide antibiotics. Clindamycin is suitable for patients with a penicillin allergy. Here you can read everything about Clindamycin.
How Clindamycin works
Clindamycin inhibits the ability of the bacteria to produce proteins. Since proteins for the construction of the bacterial cells are, however, extremely important to the antibiotic prevents the growth and reproduction of bacteria.
Pharmacokinetics and metabolism of Clindamycin
Clindamycin is absorbed into the body after administration by mouth well through the gastrointestinal tract. An administration in a venous blood vessel or into a skeletal muscle using a syringe and cannula is also possible. The active substance is metabolised largely by the liver and excreted in the faeces and subsequent urine. A small part of leaving the body in an unchanged form.
Clindamycin can also be applied externally: In the form of a vaginal cream or gel, the antibiotic inhibits bacterial growth at the site of application
When is Clindamycin applied?
Since Clindamycin is good tissue penetration and accumulates in bone tissue, it is used in infections of bones and joints (eg. as osteomyelitis, septic arthritis) and of the tooth and jaw area infections for use.
Further fields of application (indications) of the antibiotic are:
- infections of ear, nose and throat area (z. B. acute middle ear, sinuses almond and sore throat)
- infections of the lower respiratory tract (eg. as pneumonia)
- infections of the pelvic and abdominal cavity and the female reproductive organs (eg. as vaginitis)
- skin infections (z. B. common acne)
- infections of the soft tissues
How Clindamycin is used
Clindamycin tablets or capsules to be taken with plenty of fluids without food.
For a Clindamycin dry juice a ready for use suspension must be prepared prior to first use. These cold, previously boiled water is added to below the mounted on the bottle label. The bottle is sealed and shaken well, until the granulate has completely dissolved. Once the foam has completely settled, it is filled exactly up to the mark. The reconstituted suspension should be shaken well before each use.
The daily dose between 0.6 and 1.8 grams Clindamycin and depends on the type and severity of the infection. It is spread over three to four doses. The duration of use depends on the underlying disease and the disease course and is therefore determined by the doctor.
A Clindamycin vaginal cream is introduced with an applicator into the vagina. The treatment should be done before going to bed and not be initiated during menstruation.
Clindamycin in the form of gel is applied thinly to the diseased skin areas and should not be brought into contact with eyes or mucous membranes.
What are the side effects of Clindamycin?
Especially when taking over the mouth can Clindamycin, strong diarrhea with admixture of blood, abdominal cramps and nausea accompanied. In case of diarrhea, the antibiotic should therefore discontinued as a precaution and seek medical attention.
If more than one percent of patients occurs during use of Clindamycin in a slight, temporary increase in certain liver enzymes (serum transaminases). After administration of a venous blood vessel can lead to pain and with subsequent clot formation (thrombophlebitis).
When applied to the skin can Clindamycin side effects such as dry skin, redness, burning and cause.
What should I watch for while taking Clindamycin?
Clindamycin should not be used in case of hypersensitivity to Clindamycin or lincomycin. In patients with hepatic impairment, disturbance of signal transmission from nerve to muscle (z. B. myasthenia gravis, Parkinson’s disease) and gastrointestinal disease in history (eg. For example, inflammation of the colon), special caution is required.
Pregnancy and lactation
Since there are insufficient data for Clindamycin, the drug during pregnancy and lactation should not be used. As a precaution, should stop breast-feeding before starting treatment nursing mothers.
The antibiotic can reduce the effectiveness of the contraceptive pill. As a precaution, should therefore be prevented in addition mechanically during treatment (eg. As with condoms).
A concomitant use of Clindamycin and macrolide antibiotics (such as Erythromycin, Clarithromycin, Azithromycin or Roxithromycin) does not make sense, since both agents act in the same way and thereby weaken each other in their effect.
Clindamycin may enhance the effects of muscle relaxants (drugs which lead to a temporary relaxation of skeletal muscle) because the antibiotic also has a muscle-relaxing effect. The dosage of muscle relaxants should be adjusted by the physician accordingly.
How to receive medication with the drug Clindamycin
preparations with Clindamycin are available by prescription and is available only by prescription in pharmacies.
Since when Clindamycin is known?
Clindamycin is chemically closely related to lincomycin, which is produced by certain bacteria (Streptomyces lincolnensis) and was discovered in the 1950s – in ground crops near the town of Lincoln, Nebraska (hence the name Lincomycin) , Clindamycin is obtained by a chemical reaction of lincomycin. Compared to this, it is more effective and is better absorbed into the body. Clindamycin is since 1968 on the market.
What you should also know about Clindamycin
As with Clindamycin the natural bacterial colonization of the intestine is altered, it may cause diarrhea. Preventive products with special drug-yeast (z. B. Saccharomyces cerevisiae) can also be taken.