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The active ingredient Orlistat inhibits fat digestion and is used as a cure for obesity. He is mostly not absorbed by the intestine into the body, which hardly severe side effects occur. Here you can read everything of interest to Orlistat, side effects and use.
How Orlistat works
After the absorption of dietary fats pour stomach and pancreas specific lipolytic enzymes called lipases from. The movement of the muscle walls of the digestive tract of the food pulp with the enzyme-containing digestive juice is blended. The lipases cleave the dietary fats into their components (glycerol and fatty acids), which can then be taken up through the intestinal wall.
Orlistat is a so-called lipase inhibitor: it blocks the lipases in the stomach and small intestine. Without enzymatic cleavage but can not get dietary fats in the blood and are instead excreted in the stool. Since fat the nutrient with the highest caloric density (about 39 kilojoules per gram or 9.3 kilocalories per gram of fat), can be reduced by inhibiting the digestion of fat effectively the calorie intake. This is particularly useful for obese people to assist in weight loss for a fundamental change in diet.
After taking Orlistat, the active ingredient starts right in the stomach and intestines to work. It is absorbed into the blood through the intestine only in trace amounts and happened largely unchanged the intestine.
When is Orlistat used?
The active ingredient Orlistat is used in conjunction with a reduced calorie diet in patients with a body mass index (BMI) of 30 or more. For existing risk factors, the lipase is already given with a BMI of 28 or more. During twelve weeks after the start of application not less than five percent of the initial weight were taken, the treatment should be discontinued.
How Orlistat is used
The active ingredient Orlistat is used in the form of capsules or chewable tablets. Each chewable tablet or a capsule containing up to 120 milligrams of Orlistat is immediately before, during, or taken up to an hour after eating a large meal. The intake should be done only when the meal fats or oils has included.
What are the side effects of Orlistat?
During the treatment, it comes with more than one in ten patients on Orlistat side effects such as, fatty stools, bloating with defecation, tenesmus and liquid stools.
More side effects with every tenth to hundredth treated are about fatigue, menstrual cramps, anxiety, urinary tract infection, pain in the rectum (Rectal), fecal incontinence, tooth and gum problems.
What should be considered when taking Orlistat?
The concomitant use of ciclosporin should be monitored by a doctor because of the blood levels of the immunosuppressant may be lowered through the fat inhibitor. Ciclosporin is administered in chronic inflammatory bowel disease, atopic dermatitis, psoriasis and organ transplantation.
In the simultaneous use of oral anticoagulants the coagulation value (INR or Quick-value) should be closely monitored.
Because fat-soluble vitamins (vitamins A, D, E and K) and beta-carotene (provitamin A) are added dissolved in dietary fat, which can lead to taking Orlistat to a corresponding vitamin deficiency. Therefore, the patient in his diet should pay particular attention to a high proportion of fruit and vegetables. If necessary, vitamin supplements can also be taken.
Patients taking HIV drugs, antidepressants or antipsychotics (for mental disorders) should first discuss the use of Orlistat with a doctor. There are reports that the effect of these drugs is obviously affected by the lipase.
For use of Orlistat during pregnancy No data are available. Pregnant women should therefore take the lipase only under medical supervision.
During lactation Orlistat should not be used because it is not known whether it is excreted in human milk.
The use in humans under 18 years, the elderly or people with liver and kidney disease has not been studied, which is why the drug should not be used here.
How to obtain drugs Orlistat
chewable tablets and capsules with up to 60 milligrams per single dose Orlistat are apothekenpflichtig and can be purchased over the counter in pharmacies. Higher-dose drugs are available, but are only available on prescription.
Since when Orlistat is known?
The active substance in part by synthesis is a chemically modified derivative of the substance lipstatin, which is formed by certain Actinobacteria. By chemical modification increased stability has been achieved while maintaining efficacy. A preparation containing Orlistat has been marketed in Germany for the first time in 1998 by the pharmaceutical company Roche for approval. In 2007, the prescription requirement for low-dose drug was repealed with Orlistat in the US, in 2009 the same thing happened in the European Union. There are now on the German market also generics with the active ingredient Orlistat .