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Last Updated on March 16, 2024

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The active ingredient Glimepiride is one of the most important remedies for type 2 diabetes by helping to stimulate the body’s release of insulin. He is generally well tolerated, can lead to hypoglycaemia in rare cases, however. Children and pregnant women should take medication containing Glimepiride, only after consultation with the doctor. Here you can read everything about Glimepiride.

How Glimepiride works

Each cell in the body must have at its energy in order to function well can. The most important source of energy are carbohydrates, which are supplied through the diet. In the digestive tract, they are broken down into their smallest components (simple sugars), since only these can be absorbed through the intestinal wall into the bloodstream. Thus, the sugar can pass from the blood into the cells of the body, it takes the hormone insulin. It “helps” the sugar to reach the interior of the cells.

In the diabetes type 2 (type 2 diabetes), the cells respond less and less to insulins at what the sugar intake affect – the blood sugar level is increased, resulting in long term damage to blood vessels and nerves. Possible symptoms are as cardiovascular disease, kidney, eye and nerve damage.

Glimepiride (active ingredient from the group of medicines called sulfonylureas) stimulates the body to increased insulin secretion, to lower blood sugar levels. Such hypoglycemic agents are type 2 diabetics but only prescribed if other measures (such as change in diet, more exercise) blood sugar levels could not cut enough.

Pharmacokinetics and metabolism of Glimepiride

After recording via the mouth (orally), the active ingredient is fully absorbed into the blood from the gut and distributed throughout the body. Finally, it is metabolized in the liver and excreted in the urine and stool.

When is Glimepiride used?

For application (indication) of Glimepiride belongs:

  • treatment of type 2 diabetes, when weight loss, exercise and diet to elevated blood glucose levels could not reduce sufficiently

How Glimepiride is taken?

Glimepiride is applied in the form of tablets. In general, one begins with a dose of one milligram per day. Depending on individual metabolism, the doctor may increase the dose to a maximum of six milligrams.

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The tablets are usually taken once a day. It may be taken before or with the first main meal of the day.

In spite of medication use have type 2 diabetes continue to pay attention to a healthy body weight or reduce overweight, heed certain nutritional advice and exercise regularly and sufficiently.

What are the side effects of Glimepiride?

Rare, ie with less than one percent of those treated, causes side effects such as allergic reactions Glimepiride, blood sugar (hypoglycaemia), gastrointestinal complaints, and changes in blood count.

By taking agents that increase insulin release, it may be a coming to an increased feeling of hunger and related. Therefore, it is especially important to pay attention to a healthy diet.

What should I watch for while taking Glimepiride?

drugs with Glimepiride should because of side effects not be used in patients who are severely overweight.

Never Glimepiride when an insulin dependent diabetes is present or the patient suffers from severe kidney or liver dysfunction.


In a simultaneous intake by the following means the action of Glimepiride can be strengthened:

  • insulin or other antidiabetic agent
  • phenylbutazone (remedy for rheumatic diseases)
  • anabolic steroids and male hormones
  • Chloramphenicol (antibiotic)
  • phenprocoumon (used to thin the blood)
  • fibrates (used to lower elevated levels of blood lipids such as cholesterol)
  • Captopril, Enalapril, Ramipril (remedy)

The following resources reduce the hypoglycaemic effect of Glimepiride:

  • female hormones (estrogens)
  • diuretics (water tablets)
  • Cortisone (anti-inflammatory agent)
  • thyroid hormones
  • Adrenalin
  • laxative

Even with alcohol can lead to unpredictable interactions. Therefore, experts advise against the simultaneous alcohol consumption.

Driving and using machines

In particular, at the beginning of treatment may lead to unexpected bouts of hypoglycemia, which can lead to and fainting. Therefore, attention must be given to the individual tolerance. It is best to discuss with a doctor to see if you may participate despite Glimepiride application active before driving or operating heavy machinery.


In general, diabetes type 2 occurs on only at an older age. Accordingly, very few data are available for the use of the product in children and adolescents. Before use in patients in this age group, a benefit-risk assessment should be done by an experienced doctor.

Pregnancy and lactation

In a gestational diabetes oral agents for diabetes (such as Glimepiride) should not be applied. Instead insulins that are injected, agents are the first choice.

How to get medicines with Glimepiride

drugs with Glimepiride are available on prescription, since the treatment of type 2 diabetes requires regular visits to the doctor. You get it therefore only with a prescription from a doctor in pharmacy.

Since when Glimepiride is known?

sulfonylureas are already longer than hypoglycemic agents in diabetes in use. The development of older members of this drug class has led in 1996 to the introduction of Glimepiride .

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