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Last Updated on March 16, 2024

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The active ingredient Isotretinoin is one of the most important drugs in acne. He was admitted in 1982 in the US and is still successfully used in acne therapy. Isotretinoin can be applied internally and externally and generally shows a very good activity. Pregnant and lactating women, however, may under no circumstances take the drug. Here you can read everything about Isotretinoin.

How Isotretinoin works

The active substance is a so-called retinoid, therefore a natural derivative of vitamin A, also known as retinoic acid. Retinoids are used everywhere in the body and ensure in the cells for accelerated growth.

In severe forms of acne clog pores by an increased activity of the sebaceous glands. This can then become inflamed, resulting in the typical purulent pimples and acne patients.

If the body is fed to an additional amount of retinoids, such as Isotretinoin, it comes after binding to the docking sites (receptors) to an increased cell growth in the upper layers of skin (epidermis). The stratum corneum of the skin loosens up, and a “peeling” of the epidermis is facilitated. In addition, the function of the sebaceous glands is affected, whereby the pores become clogged less.

Overall, the skin is cleansed from the inside out, the skin becomes more refined and there are less impurities.

Pharmacokinetics and metabolism of Isotretinoin

The active ingredient Isotretinoin is incompletely absorbed after ingestion by mouth (oral) from the intestine into the blood (at about 25 percent). Thereafter, the degradation takes place in the liver. The degradation products are excreted about equally in the urine and stool.

When applied to the skin, for example in the form of a gel, only a slight absorption takes place in the blood. The effect is limited in practice locally, whereby fewer side effects.

When is Isotretinoin used?

Among the areas of application (indications) of the active ingredient Isotretinoin include mild and severe forms of acne. Isotretinoin is thereby applied externally or internally, depending on the severity of the disease. may be used in particularly serious forms in the form of tablets.

HowIsotretinoin is used

In milder forms of acne a topical treatment in the form of an Isotretinoin cream or a gel is first tested. The preparation is usually switched thinly twice a day to the affected skin.

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In severe cases of illness Isotretinoin is swallowed in the form of soft capsules. The daily dose is usually 0.5 to 1 milligram per kilogram of body weight. A 70-kilogram patient would take between 35 and 70 milligrams So Isotretinoin daily.

In order to improve compatibility of the drug should be taken with food.

What are the side effects Isotretinoin?

Very often, that is at more than ten percent of those treated, calls Isotretinoin side effects such as skin and eye dryness, allergic skin reactions and forth.

Very rarely can occur by ingesting about behavior problems, vision problems, worsening of hearing, respiratory and gastrointestinal ailments.

What should I watch for while taking Isotretinoin?

Experts, during treatment with Isotretinoin to steer clear of alcohol.

The active ingredient Isotretinoin adds unborn too much damage. Therefore, patients must apply at least one safe method of contraception during treatment absolutely. It is also recommended once a month to perform a pregnancy test before starting treatment and during treatment. The result must be documented by the attending physician.

To Isotretinoin therapy in male patients. In the sperm is virtually no active ingredient to find out why a damaging effect on the fetus in unprotected intercourse is probably exclude


In the following cases, medication with Isotretinoin should not be used:

  • Pregnancy
  • breastfeeding
  • hepatic impairment
  • strongly elevated blood lipids (such as high cholesterol)
  • overdose with vitamin A
  • Simultaneous treatment with Tetracyclines (medicines for bacterial disease)


medication with Isotretinoin should not be administered along with other vitamin A supplements, because otherwise there is a risk of overdose.

Driving and using machines

In rare cases it can lead to night blindness and drowsiness when taking Isotretinoin. In particular, at the beginning of therapy should therefore always be paid to the individual response to the drug before actively participating in driving or using heavy machinery.


The drug Isotretinoin may be applied only from the age of 12 years.

How to obtain medication with Isotretinoin

medication with Isotretinoin are available by prescription, because the treatment requires regular medical checks. You get it therefore only with a prescription from a doctor in pharmacy.

Since when Isotretinoin is known?

The active ingredient Isotretinoin was approved in 1982 in the US for the first time. Already at that time was its teratogenic (teratogenic) effects known. It is believed that Isotretinoin even stronger, “teratogenic” acts as thalidomide. This ingredient has been used in the 1980s under the brand name “Contergan” as sleeping pills and tranquilizers, which eventually led to the “thalidomide scandal”: Many pregnant women who had taken the drug, brought children with severe deformities. Since tests are required prior to approval of a new drug, which monitor the effects of income on the unborn child.

What you should know about Isotretinoin

The treatment with Isotretinoin may initially lead to a worsening of the symptoms of acne (called “blooming” of acne). This indicates the effectiveness of the drug. If therapy with Isotretinoin but continued, the symptoms improve quickly.

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