Last Updated on March 16, 2024
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Cefixime
The active ingredient Cefixime is an antibiotic from the group of the third generation cephalosporins. It acts against a broad spectrum of bacterial pathogens. Cephalosporins are closely related to the penicillins, which is why when penicillin allergy is usually against an allergy cephalosporins (cross-allergy). Here you can read everything you need to Cefixime: application, effects and side effects
How Cefixime works
Bacteria protect themselves from harsh environmental influences by in addition to a cell membrane (as they also have animal cells) form a solid cell wall. This causes mainly an increased resistance against external influences such as different salt concentrations in the environment. On the basis of differently formed cell wall of bacteria are also classified by the so-called Gram stain.
In order to multiply, the bacterial cells divide under favorable environmental conditions constantly – some bacteria even every twenty minutes. For this purpose, the stable cell wall must be broken and then added again and controlled cross-linked.
Beta-lactam antibiotics such as penicillins and cephalosporins (which would include Cefixime) inhibit the bacterial enzyme transpeptidase. It provides for the cross-linking between individual cell wall components (sugar and protein compounds), whereby a robust outer shell is formed. If the transpeptidase is inhibited, the cell is still trying to share under the appropriate conditions, but the vacancies after the division can no longer close their cell wall. This makes them very sensitive to their environment and is usually killed quickly – that’s why it is also called in Cefixime from a “bactericidal antibiotic ‘
Early one noticed, especially in the penicillins, that bacteria quickly adapt to their environment due to their rapid rate of division itself. Through changes to their genetic material (mutations) that happen constantly, some bacteria can produce the enzyme beta-lactamase. This is able to degrade beta-lactam antibiotics of the first generation, which no longer affect them. However, Cefixime is beta-lactamase stable, making it effective against a wider range of bacterial pathogens than the previous penicillins and other cephalosporins.
Pharmacokinetics and metabolism of Cefixime
After taking a tablet or dissolved in water Cefixime is captured about halfway out of the intestines into the blood and reached there after three to four hours, the highest blood levels. Cefixime is not converted or degraded in the body. It is conveyed after recording the most part by the kidneys from the body. About four hours after taking half of the captured drug is excreted in the urine.
When is Cefixime used?
The antibiotic Cefixime is approved for the treatment of:
- bacterial respiratory infections
- bacterial infections in the field of Ear, Nose and Throat
- biliary infections
- urinary tract infections
The use of Cefixime is only shortly after doctor’s orders. The antibiotic may no longer, but not shorter than prescribed to be taken, since this can make bacterial resistance else.
How Cefixime is used
Usually, Cefixime is taken in pill form or as a suspension (made of pellets or beverage tablets). Most 400 milligrams twice daily Cefixime or 200 milligrams of Cefixime over a period of five to ten days are prescribed once daily. In uncomplicated urinary tract infections of the woman, the doctor may reduce the duration of treatment on one to three days. The antibiotic may be taken with or without food.
What are the side effects Cefixime?
The most common side effect that may occur during treatment with Cefixime, are diarrhea and soft stools, as the drug is attacking the beneficial intestinal bacteria and kills.
Sometimes it also comes at a hundred to a thousand of those treated for Cefixime side effects such as indigestion, nausea, vomiting, elevated liver enzymes and rashes.
If there are signs of an allergic reaction (, dyspnoea), a doctor must be informed and the administration of Cefixime are finished.
What should I watch for while taking Cefixime?
If the antibiotic Cefixime in combination with other agents that may affect renal function, renal function can be greatly reduced. This is the case for the antibiotics gentamicin, colistin and polymyxin and potent agents such as ethacrynic acid and Furosemide dehydration.
At the same time taking Cefixime with the blood pressure medication Nifedipine recording from the intestine is greatly increased in the blood.
The additional intake of anticoagulant drugs of the coumarin-type (such as phenprocoumon and warfarin) may result in an increased risk of bleeding. Therefore, the coagulation tests should be closely monitored while you are taking.
For taking Cefixime in pregnancy and lactation are only a few data are available. As a precaution should therefore be dispensed with at this time on the antibiotic.
and preterm newborn infants up to one month Cefixime should not take. However, children and adolescents can be treated in a correspondingly reduced dosage with Cefixime. The same is true for older patients. In a patient with renal insufficiency, where appropriate, the dose of Cefixime should be reduced.
How to get Cefixime
The antibiotic Cefixime is only available on prescription in any dosage and package size. So it is only available by a prescription at the pharmacy.
Since when Cefixime is known?
The first cephalosporin was discovered in 1945 at the University of Cagliari: It was (today Acremonium chrysogenum) isolated from the fungus Cephalosporium acremonium. Due to its penicillin-like structure, the researchers suspected that even powerful antibiotics could emerge from it by a specific chemical change. Today it is already third generation cephalosporins as just a Cefixime .
