Last Updated on May 3, 2024
Cefaclor is an antibiotic commonly used to treat a wide range of bacterial infections. While it is available on prescription in most countries, there are some places where it can be bought over the counter without a doctor’s prescription. Unfortunately, the UK is not one of these places.
If you want to buy cefaclor in the UK, you will need a prescription from a registered healthcare professional. This is because antibiotics are classed as prescription-only medicines in the UK and can only be obtained from a licensed pharmacy. There are no exceptions to this rule, so if you see advertisements for cefaclor being sold over the counter, it is best to avoid them.
If you are prescribed cefaclor in the UK, you can expect to receive either a capsule or a suspension to be taken by mouth. The dosage and duration of treatment will depend on the specific infection you have and your individual health needs. It is important that you follow your doctor’s instructions carefully to ensure that you get the full benefit of the medicine and reduce the risk of side effects.
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What is cefaclor?
Cefaclor is an antibiotic in the cephalosporin group. It belongs to the second generation of cephalosporins and, unlike the first generation, it is also more effective against so-called gram-negative bacteria. Read more about how cefaclor works, how it is used, side effects and other important information.
How does cefaclor works?
The antibiotic cefaclor works like other cephalosporins against bacteria. Bacteria can be distinguished from Gram-positive and Gram-negative (non-dyeable) bacteria by the structure of their cell walls. Many antibiotics act on a part of the bacterial cell wall and can thus prevent their growth and reproduction. Unlike many other antibiotics, cefaclor is effective against both Gram-positive and Gram-negative bacteria.
In order for bacteria to grow, they need to break down their cell wall at specific points using certain enzymes and then rebuild and cross-link it when growth is complete. This continuous process ensures that bacteria can usually adapt very well to different environmental conditions.
By inhibiting the enzymes responsible for rebuilding the cell wall, the bacteria are killed directly, but their growth and reproduction are greatly inhibited. This allows the immune system to quickly get the infection under control. cefaclor is able to inhibit these bacterial enzymes.
Pharmacokinetics and metabolism of cefaclor
After ingestion, cefaclor is absorbed into the bloodstream in the upper part of the intestine and reaches peak blood levels within an hour. It spreads rapidly throughout the tissues, so that after four to six hours there is no detectable drug in the blood. cefaclor is not metabolised by the body, but is chemically unstable when dissolved in water, resulting in inactive degradation products. Excretion is mainly through the kidneys in the urine.
When is cefaclor used?
Cefaclor is effective against infections caused by bacteria that are sensitive to this antibiotic. This includes many pathogens that cause infections of the respiratory tract, nose, ears, kidneys and urinary tract, skin and soft tissues.
The medically recommended duration and dosage of cefaclor should be strictly adhered to, even if the symptoms disappear quickly. Otherwise, a cefaclor-resistant infection may develop.
How cefaclor is taken?
Cefaclor has limited stability in aqueous solution and is therefore only available in the form of tablets, capsules, effervescent tablets or powder for reconstitution. Dry juices are filled before a certain amount of water is added, which produces the actual cefaclor juice (actually a suspension, i.e. powder particles in liquid). As these particles fall off over time and the drug accumulates on the bottom, the bottle should always be swirled (not shaken to avoid foaming) before use. Single-dose forms (tablets, capsules, effervescent tablets) are easier to take.
Adults and children over the age of ten usually take 500 milligrams of cefaclor three times a day. In severe infections, your doctor may increase the dose of cefaclor up to 4,000 milligrams a day. Younger children are given lower doses according to their body weight. Children under the age of six should be given a liquid form (effervescent tablet or juice) as they may have problems swallowing tablets and capsules.
What are the side effects cefaclor?
The active ingredient cefaclor may cause side effects such as gastrointestinal symptoms and allergic skin reactions in ten to one hundred patients (redness, swelling). Since allergic reactions can be serious, a doctor should be informed.
Occasionally (one out of one hundred to one thousand patients) cefaclor side effects show such as sleep problems, fatigue, confusion, dizziness, seizures, and increased blood urea levels and blood enzymes.
What should I watch for while taking cefaclor?
Cefaclor should not be taken together with other antibiotics (such as erythromycin, chloramphenicol and tetracycline) as they may interfere with each other.
Anticoagulants such as warfarin and phenprocoumon may be increased by cefaclor and may cause bleeding.
Taking cefaclor can speed up the passage of other medicines through the gastrointestinal tract and they may not be absorbed completely. This is known to happen with the contraceptive pill, for example, so to be on the safe side you should also avoid taking non-hormonal contraceptives during antibiotic therapy.
Patients who are allergic to penicillin may also be allergic to cephalosporins such as cefaclor (cross-allergy).
Although studies to date have shown no adverse effects in pregnancy, cefaclor should not be used by pregnant women if safer alternatives are available.
A small amount of cefaclor passes into breast milk. As a result, the active ingredient disrupts the colonisation of the baby’s intestines with bacteria. In urgent cases, antibiotic therapy should therefore be stopped.
Cefaclor may be used in reduced doses in children, the elderly and patients with impaired kidney function.
How to get medicines containing cefaclor
Antibiotics such as cefaclor can only be obtained from a pharmacy on prescription in any dosage.
How long has cefaclor been on the market?
The cephalosporins were all developed from a substance discovered in Italy in the 1940s from a fungus called Acremonium chrysogenum (formerly Cephalosporium acremonium). This material was very interesting for medical applications at the time because it was effective against the disease, something that penicillin could not do at the time. Chemical modifications in the laboratory have led to the development of many cephalosporins with improved properties over the past decades. cefaclor was approved in Europe in the 1970s and is also a component of many generic medicines.
