Last Updated on March 16, 2024
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Cefaclor
The active ingredient Cefaclor is an antibiotic from the group of cephalosporins. It belongs to the second generation of cephalosporins and acts in contrast to the first generation also reinforced against so-called gram-negative bacteria. Here you can read more about the impact and use of Cefaclor, side effects and other important facts.
How Cefaclor works
The antibiotic Cefaclor works like other cephalosporins against bacteria. These are (dyeable under the microscope by a particular coloring) due to the structure of their cell wall in Gram-positive and Gram-negative (non-dyeable) distinguish bacteria. Many antibiotics affect a building of the bacterial cell wall and thus can prevent their growth and reproduction. In contrast to many other antibiotics effective against Cefaclor against both gram-positive and gram-negative bacteria.
To the growth of the bacteria they must dissolve their cell wall at specific points with the help of certain enzymes and rebuild it and crosslink after completion of growth. This continuous process ensures that bacteria can usually very well adapted to different environmental conditions.
Now you inhibit the corresponding enzymes, which are responsible for the reconstruction of the cell wall, the bacteria are killed directly, but inhibited in their growth and reproductive rate far. So can get the infection under control quickly the immune system. With Cefaclor such inhibition of bacterial enzymes is possible.
Pharmacokinetics and metabolism of Cefaclor
After taking Cefaclor is received in the upper portion of the intestine into the bloodstream and to a large extent achieved after one hour, the highest blood levels. It spread rapidly in the tissue, so that after four to six hours, no more drug is undetectable in the blood. Cefaclor is not metabolized by the body, however, it is dissolved in water chemically unstable, causing inactive decomposition products are formed. Excretion is mainly via the kidneys in the urine.
When is Cefaclor used?
The active ingredient Cefaclor is effective against infections caused by bacteria sensitive to this antibiotic. This includes many pathogens, the respiratory infections, nose, ears, kidneys and urinary tract, skin and soft tissue cause.
The medically recommended duration and Cefaclor dosage should be strictly adhered to, even if symptoms resolve quickly. Otherwise, possibly developed a Cefaclor-resistant infection.
How Cefaclor is taken?
The antibiotic Cefaclor is limited stability in aqueous solution, which is why it is placed only in the form of tablets, capsules, effervescent tablets or powders for reconstitution in the so-called trade. Dry juices are filled before taking a certain amount of water with, whereby the actual Cefaclor juice (actually a suspension, ie powder particles in fluid) is produced. As these particles fall with time and the drug accumulates on the ground, before taking the bottle always swirled should (not shaken, so that no foam is formed) are. The single-dose dosage forms (tablets, capsules, effervescent tablets) in this regard are easier to handle in the intake.
Adults and children and adolescents over ten years take usually three times daily 500 milligrams a Cefaclor. In severe infections the Cefaclor-dose may be increased by your doctor up to 4,000 milligrams per day. Younger children will receive in proportion to their body weight lower dosages. For children under six, a liquid dosage form should be selected (effervescent tablet or juice), as sometimes there are problems with swallowing tablets and capsules at this age.
What are the side effects Cefaclor?
The active ingredient Cefaclor can (, redness, swelling) result in a ten to one hundred patients to side effects such as symptoms of gastrointestinal tract and allergic skin reactions. Since allergic reactions possibly be serious, a doctor should be informed.
Occasionally (one out of one hundred to one thousand patients) show Cefaclor side effects such as sleep problems, fatigue, confusion, dizziness, seizures, and increased blood urea levels and Blutenzym-.
What should I watch for while taking Cefaclor?
The intake of Cefaclor along with other antibiotics (such as Erythromycin, Chloramphenicol and Tetracycline) should be avoided, because the substances may interfere with each other in their mode of action.
Anticoagulants such as warfarin and phenprocoumon can act strengthened by taking Cefaclor and may cause bleeding.
When taking Cefaclor triggers may get other medicines accelerated through the gastrointestinal tract and thereby may not be completely absorbed. This is known, for example, the pill for contraception, so for safety’s sake in addition non-hormonally should be prevented during antibiotic therapy.
Patients who have a penicillin allergy, can possibly also allergic to cephalosporins such as Cefaclor (so-called “cross-allergy”).
Although studies to date have demonstrated no adverse effects in pregnancy, Cefaclor should not be taken by pregnant women, when there are safer alternatives.
For a small portion goes Cefaclor into breast milk. As a result, the active ingredient in the infant disrupt the intestinal colonization with bacteria. In urgent cases, antibiotic therapy should therefore be discontinued.
Cefaclor can be used in reduced doses in children, the elderly and patients with impaired renal function.
How to obtain medicines containing the active ingredient Cefaclor
antibiotics like Cefaclor may be obtained in any dosage only according to medical prescription with a prescription at the pharmacy.
Since when Cefaclor is known?
The cephalosporins have all been developed, which was discovered in the 1940s in Italy from a course in mushroom Acremonium chrysogenum(previously Cephalosporium acremonium) occurring substance. This material was then very interesting for medical applications, because it is effective against the disease, which at that time already known penicillin can not do. By chemical changes in the laboratory many cephalosporins were developed with improved properties over the past decades. Cefaclor has already been approved in the 1970s in Europe and is also a component of many generic drugs.