Last Updated on March 16, 2024
What is Trazodone?
Trazodone is an antidepressant medication. It affects chemicals in the brain which may be unbalanced in individuals with depression.
Trazodone is used as a treatment for major depressive disorder.
Trazodone may also be used for purposes not listed in this medication guide.
The active ingredient Trazodone is a medication used to treat depression (antidepressant). In addition to its antidepressant action he also has a calming and sleep-inducing effect. They are used in the form of tablets. Here you can read all about the antidepressant Trazodone: action, application and side effects and interactions.
Important Details
Trazodone should not be used by you if you’re being treated with methylene blue injection, or if you’re allergic to it.
Do not use trazodone for those who have taken an MAO inhibitor In the past 14 days. A dangerous drug interaction may occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
Some Individuals have ideas about suicide when taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using trazodone. Your family or caregivers should be alert to changes in your mood or symptoms.
Report any new or worsening symptoms for example: mood, to your doctor or Behavior changes, anxiety, panic attacks, difficulty sleeping, or if you feel spontaneous, irritable, agitated, hostile, aggressive, nervous, hyperactive (mentally or physically), more miserable, or have ideas about suicide or hurting yourself.
Don’t give this medicine to anyone younger than 18 years old with no A doctor’s advice. Trazodone isn’t approved for use in children.
Trazodone should be used with care by
- Elderly folks.
- Young adults.
- People who have a history of suicidal behavior or thoughts.
- People who have a history of psychotic illness such as schizophrenia, mania, hypomania or manic depression (bipolar affective disorder).
- Individuals with decreased liver function.
- People with decreased kidney function.
- Individuals with heart disease, such as angina, irregular heartbeat (arrhythmia), heart block.
- Individuals with an overactive thyroid gland (hyperthyroidism).
- Individuals with epilepsy.
Trazodone should not be employed by
- kids and adolescents under 18 decades of age.
- People who’ve recently had a heart attack.
- Individuals that are in a manic episode.
- Individuals who have taken a monoamine oxidase inhibitor antidepressant (MAOI) in the past two weeks.
- Trazodone capsules and tablets contain lactose and should not be taken by people with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
This Medication shouldn’t be used if you’re allergic to one or any of its components. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If You feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines shouldn’t be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to your unborn infant. Always inform your doctor if you’re pregnant or arranging a pregnancy, before using any medicine.
- The safety of this medication for use during pregnancy hasn’t been fully established. You should get advice if you think that might be pregnant or need to try to get a baby while it is being taken by you. Do not stop taking the medication suddenly as this can lead to withdrawal symptoms (see just how can I take it over). The medication should be used with caution during pregnancy and only if the benefits to the mother outweigh any risks. It should ideally be avoided in the first trimester. Should you take this medicine and you are still taking it up until you go into labor, the infant needs to be monitored for possible withdrawal effects after it’s born. Seek medical advice from your physician.
- This medicine may pass into breast milk in little quantities. It needs to be used with caution from moms who are breastfeeding, and when the potential benefits outweigh any risks. Seek further advice from your doctor.
Possible side effects of Trazodone
Medicines And their side effects can affect individual people in different ways. The following are. Because a side effect is stated this does not necessarily mean that all people using this medicine will experience that or any side effect.
- Drowsiness.
- Dizziness.
- Headache.
- Blurred eyesight.
- Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting.
- Feeling weak.
- Weight loss.
- Dry mouth.
- Altered taste.
- A drop in blood pressure that occurs when going from lying down to sitting or standing, which results in dizziness and lightheadedness (postural hypotension).
- Fluid retention resulting in swelling (oedema).
- Confusion.
- Memory Issues.
- Restlessness.
- Tremor or twitching.
- Pins and needles sensations.
- Skin rash.
- Increased sweating.
- Reduced sex drive.
- Nightmares.
- Pain in the chest, back, muscles or joints.
- Disturbances in the normal numbers of blood cells in the blood. Tell your doctor immediately if you experience any of these symptoms, because they might indicate a problem with your blood cells: unexplained bruising or bleeding, purple spots, sore throat, mouth ulcers, high temperature (fever), feeling tired or general illness. Your physician may want to take a blood test to check your blood cells.
- Liver problems, eg jaundice (yellowing of the skin and eyes). Tell your physician if you encounter this, or other potential signs of liver complications, such as loss of appetite, stomach pain, nausea and vomiting or feeling poor.
- Persistent painful erection of the penis (priapism – see warning above).
- Increase or reduction in heart rate.
- Abnormal heartbeats (arrhythmias).
- Convulsions.
The Side effects listed above may not include all of the side effects reported from the medication’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
If You feel you have experienced a negative effect from vaccine or a medication you should check the patient information leaflet. This lists the known side effects if you get them and what to do. You can also get advice. If they believe is necessary they will report it for you.
You might even report unwanted effects yourself with an yellow card site: www.mhra.gov.uk/yellowcard.
Alcohol interaction
The use of drinks that contain alcohol can increase your risk of sleepiness or dizziness from trazodone. If you drink alcohol, talk to your doctor.
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The active ingredient Trazodone subject in each dosage and package size of the recipe and pharmacies required.
The antidepressant was in the 1960s in Italy by the pharmaceutical company Angelini Research Laboratories as an active ingredient of the second generation (with enhanced properties) developed. It was first approved in the US in 1981, then from 1985 also in many European countries. Ever since the patent protection has expired, many inexpensive generics came with the drug Trazodone on the market.
How does trazodone work?
The nerve cells (neurons) in the brain communicate with each other using chemical messengers (neurotransmitters): A cell can secrete a particular neurotransmitter, which then in certain docking sites (receptors) binds the target cell and then transmits a signal. To stop the signal, the messenger is finally resumed in the cell of origin.
With a deficit or surplus of neurotransmitters in the brain may lead to certain organic brain diseases. Known as the “happiness hormone” serotonin leads, according to experts at a deficiency to depression, with a surplus to diseases such as delusions and schizophrenia.
antidepressants such as Trazodone inhibit the reuptake of the neurotransmitter serotonin, which is why they are called selective serotonin reuptake inhibitor. Thus the messenger remains longer between nerve cells and may thus longer can work. This compensates for a lack.
In addition Trazodone also inhibits a specific group of serotonin receptors (5-HT 2receptors). Excessive activation of these receptors is associated with insomnia, restlessness, and sexual dysfunction.
This dual action effect it assigns Trazodone called “dualserotonergen antidepressants” (DSA).
After taking the drug is rapidly and completely absorbed in the intestine. The highest blood levels are reached after one hour to a half. After his breakdown in the liver of the drug is excreted through the kidneys to three-quarters in the urine. Five to eight hours after ingestion has about half of the ingested dose Trazodone leave the body.
Uses
This medicine is used to treat depression. Reduce anxiety and insomnia in addition to it could help to enhance your mood, appetite, and energy level. Trazodone operates by helping to restore the equilibrium of a certain all-natural chemical (dopamine) in the mind.
The best way to use Trazodone HCL
Read the Medication Guide provided by your pharmacist before you begin using trazodone and every time you get a refill. Ask with your health care provider or pharmacist when you have any questions.
Take this medication Generally twice or once per day after snack or a meal or as instructed by your physician. If nausea is a problem and you’re taking 1 dose each day, take it. If you’re currently taking 2 doses every day, it might help to take 1 of those doses. Follow your doctor’s directions.
Dosage Is based on your medical condition and response to therapy. Your physician may start you at a very low dose and gradually increase your dose to lower your chance of unwanted effects.
Take this medication as prescribed. Do Not increase your dose or take this medicine. Your condition won’t improve any faster, and the probability of side effects may be increased.
It’s Important to keep Taking this medicine as prescribed even when you are feeling good. To assist you remember, take it in exactly the exact same time(s) daily. Don’t stop taking this medicine without consulting with your physician. Stress, burnout, and difficulty may happen if the medication is abruptly stopped.
It May take two to four weeks until you become aware of the effects of the medication. Tell your doctor if your condition worsens or persists.
How should I take trazodone?
The antidepressant Trazodone is taken in pill form. The treatment is started gradually, so by the slow increase in the dose of Trazodone. Usually, starting with 100 milligrams per day. In each case after one week the dose may be increased to 100 milligrams up to a maximum dose of 400 milligrams per day.
The daily dose is taken either once a day or in divided doses. To be taken after a meal.
It is important to note that the sedative effects of Trazodone used immediately, the mood enhancing effect only after up to three weeks. The termination of therapy with Trazodone should be tapered off, so by slow dose reduction.
What should I assess when taking Trazodone?
The combination of Trazodone with other sedative drugs may lead to an excessive reinforcement of the sedating effect. Examples of these medicines are active against psychosis (antipsychotics / neuroleptics), hypnotics, sedatives, anti-anxiety drugs and drugs against allergies (antihistamines).
The concomitant use of substances which are metabolized by the same liver enzymes such as Trazodone may affect its degradation and thus lead to increased Trazodone levels in the body. Examples of such drugs are antibiotics (eg, Erythromycin, Clarithromycin), antifungal (ketoconazole, itraconazole) and HIV medicines containing the active substance ritonavir.
agents which increase the serotonin concentration in the brain, should not be combined with Trazodone, as it may otherwise come to life-threatening “serotonin syndrome” (having, nausea, vomiting, etc.). Such agents are, for example, antidepressants of type MAOIs (such as moclobemide or tranylcypromine), other antidepressants, St. John’s wort preparations, migraine drugs (such as Sumatriptan and naratriptan), strong painkillers (opioids such as tramadol, fentanyl and pethidine) and serotonin precursors such as tryptophan and 5-Hydroxytryptophan (5-HTP).
A monitoring of blood levels is advised with concomitant use of drugs with a so-called “narrow therapeutic index.” These are substances that must be metered very precisely, because it can quickly lead to over- and underdosing. This applies, for example, the anticonvulsant Carbamazepine and Phenytoin means and the heart medication Digoxin.
Patients taking anticoagulant (such as phenprocoumon and warfarin) should monitor their coagulation status under Trazodone therapy with particular care.
In elderly patients and patients with hepatic impairment the Trazodone dose needs to be adjusted accordingly.
For taking Trazodone during pregnancy and lactation There is limited data. Therefore it should not be at this time to take them.
The same recommendation applies to children and adolescents under 18 years. For use of Trazodone in these age groups are no data available.
