Last Updated on May 30, 2023
Terbinafine over the counter in the UK is a popular antifungal medication used to treat a variety of fungal infections on the skin and nails. Its active ingredient, terbinafine hydrochloride, is an effective fungicide that treats a range of infections caused by fungi such as tinea pedis, tinea corporis, and tinea cruris.
Although Terbinafine is a prescription-only medication, it is also available over the counter in certain forms. For example, terbinafine Hydrochloride Cream can be used to treat athlete’s foot and jock itch, while terbinafine hydrochloride Spray is effective for treating ringworm. It is important to note that these over-the-counter forms of terbinafine should only be used for specific types of fungal infections and not for nail fungus.
Terbinafine over the counter is readily available in many pharmacies and drug stores across the UK. While it may be tempting to buy this medication without consulting your doctor, it is important to seek professional medical advice before using any antifungal treatment. Your doctor can help you determine if terbinafine is right for you and can provide guidance on dosage and usage.
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What is terbinafine?
Terbinafine is used as an antifungal (antifungal) for the treatment of skin or athlete’s foot. Due to its chemical structure to count him to the group of allylamines. The treatment may be carried externally (as a cream, etc.) or internally (in the form of tablets). Here you can read everything of interest to effect and Terbinafine, side effects and interactions.
How does terbinafine work?
Like animals and humans, fungi also exist as individual, under certain conditions, individually viable cells. The cell is thus able to dress nest, an independent component of all life forms. To accurately and selectively damage during an infection with a fungus only the fungal cells, is made of the differences between life forms advantage. These differences at the cellular level is not very large (for example, the human and the mold are more closely related to each other than some types of bacteria). Therefore, many antifungal drugs are targeted at the cell membrane, which is constructed differently in fungus and humans.
In humans and many animals, the membrane that separates the cell from the outside and allows many metabolic pathways to occur is composed mainly of specific lipids such as cholesterol. Cholesterol gives the cell membrane the flexibility to respond to environmental influences. In mushrooms, this function is performed by the substance ergosterol, which is chemically similar to cholesterol but has a different structure in many respects.
The active ingredient terbinafine inhibits fungal cells from producing ergosterol. The resulting lack of ergosterol in the membrane inhibits the growth of the fungal cells or can even kill them.
Pharmacokinetics and metabolism of terbinafine
After ingestion, terbinafine is well absorbed in the intestine, but part of it is rapidly metabolized in the liver, so that only about half of the administered dose reaches the systemic circulation, where the highest levels can be measured after one and a half hours. Because the drug is highly fat soluble, it is well absorbed into the skin and nails. Half of the drug is excreted after approximately 30 hours.
Terbinafine can be reduced by many different subtypes of the cytochrome P450 enzyme needed to make it water soluble. The degradation products are excreted in the urine through the kidneys or in the stool through the intestines.
When should you use terbinafine?
The antifungal drug terbinafine is used to treat fungal infections of the skin and nails. For a skin fungal disease, it is usually applied locally (such as terbinafine cream), for a larger skin or nail fungal infection, systemically (in the form of terbinafine tablets).
They are usually used for only a few weeks for skin fungus, but may be used for three to six months for nail fungus.
How is terbinafine used?
Terbinafine is used to treat fungal skin infections in the form of a cream, gel, or spray. It should be applied once or twice a day to the affected and adjacent areas. It is used for about one to two weeks, depending on the type of infection.
For severe skin or nail fungal infections, terbinafine tablets containing 250 milligrams of active ingredient are used. The tablets are taken once a day with a glass of water. Terbinafine should be taken at the same time every day. Depending on the severity of the disease, terbinafine is usually taken for about four to six weeks (for skin fungus infection) or over a period of up to three months (for nail fungus infection).
What are the side effects of terbinafine?
While taking Terbinafine it comes with more than ten percent of those treated for), muscle and joint pain.
One out of tens to hundreds of patients reported side effects such as depression terbinafine, taste disturbance, loss of taste and fatigue.
The side effects shown here, occur mainly when taking Terbinafine. When applied to the skin, the side effects are most very much attenuated.
What should I watch for while taking Terbinafine?
Since terbinafine is metabolized by enzymes in the liver that break down many more drugs and foreign substances, concomitant use may affect the drug levels of each individual substance – thus increasing both lower:
Especially on the enzyme P450 2D6 Cytocrom metabolized drugs are broken down more slowly in combination with Terbinafine, allowing them to accumulate in the body. These include, for example, drugs used for depression (tricyclic antidepressants, selective serotonin reuptake inhibitors, MAO inhibitors), drugs that stabilize heart rhythm (class 1A, 1B, and 1C antiarrhythmics), and beta-blockers (cardiovascular drugs).
Since there is very limited data on the use of Terbinafine in pregnant women, it is advisable not to use the drug during pregnancy. The same applies to lactation. Also in children the use of Terbinafine is not recommended.
Elderly (over 65 years) can take Terbinafine but before that the liver and kidney function should be monitored. Patients with hepatic or renal impairment should not take Terbinafine.
How to get terbinafine?
Preparations for use on the skin containing not more than one percent of the active ingredient are available at the pharmacy with a prescription. Terbinafine tablets are available only with a prescription.
How long has terbinafine been on the market?
Terbinafine was launched by the pharmaceutical company Novartis in Europe in 1991 and in the United States in 1996. When terbinafine first appeared on the UK market in 1991 (and later in the USA in 1998), it effectively changed the way onychomycosis was treated. The patent expired in 2007 after an extension patent was filed in the United States for the treatment of children. In Germany, however, numerous generics containing the active ingredient terbinafine are already available.