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The active ingredient Alfuzosin helps against symptoms of benign prostatic hyperplasia. This so-called “benign prostatic hyperplasia” (BPH) often affects men in older age. It causes symptoms such as incomplete emptying of the bladder, trouble urinating and sometimes incontinence. Here you can read everything worth knowing about Alfuzosin: application, mode of action and possible interactions and side effects
How Alfuzosin affects
epinephrine and norepinephrine are two important hormones of the so-called sympathetic. The sympathetic nervous system, a part of the autonomic nervous system, has the responsibility to put the body in readiness to perform when needed (such as when sports). By using messengers such as epinephrine and norepinephrine He then ensures that important organs such as heart and skeletal muscle with abundant oxygen and energy in the form of sugar are supplied. The digestion and elimination are secondary in this situation and are therefore throttled. Excitation of the sympathetic nervous system also means that could cause the walls of the urethra and the prostate in men leads.
The latter can already at low sympathetic stimulation become a problem when a man has a benign enlarged prostate: It can then easily urination problems, incomplete bladder emptying or an occurrence. This can be very uncomfortable for men older age.
The active ingredient Alfuzosin belongs to the group of alpha-blockers. It binds to the docking sites (receptors) of adrenaline and noradrenaline, so that they can no longer be effective. The muscles of the urinary tract relaxes, reducing the symptoms of benign prostatic hyperplasia. Here Alfuzosin acts already after the first dose.
Up, degradation and excretion of Alfuzosin
After his capture of the drug from the intestine is absorbed into the blood and arrives at the muscles of the urethra and prostate. In blood it reached one to two hours after taking the highest levels.
The active substance is converted by liver enzymes in not effective degradation products that are primarily excreted in the faeces. Only a small proportion leaves the body unchanged Alfuzosin, through the urine. About five hours after taking up only half of the drug is in the body.
When is Alfuzosin used?
The active ingredient Alfuzosin is currently used only for the relief of symptoms associated with benign prostatic hyperplasia. The earlier application for lowering blood pressure has been replaced by more modern therapies with drugs.
Since the effect only lasts as long as agent acting on the muscles, must be taken Alfuzosin long term.
How Alfuzosin is applied
Alfuzosin is usually taken as a tablet. Younger than 65 years usually take three times a day and a half milligrams of Alfuzosin with a glass of water. The dose may be increased to four times daily as needed.
Patients who are older than 65 years, have renal dysfunction or due to be in treatment, the active ingredient may take only twice a day.
What are the side effects of Alfuzosin?
Alfuzosin side effects are at a ten to one hundred patients treated, malaise, nausea, abdominal pain or diarrhea. Most of these side effects occur especially at the beginning of treatment and improve in the further course.
Occasionally, it can also lead to rapid heartbeat, palpitations, blurred vision, chest pain, fluid retention, drowsiness, circulatory collapse, rhinitis, rash, hot flashes and urinary incontinence.
What should be considered when taking Alfuzosin?
The active ingredient Alfuzosin should not be taken when more alpha blockers are taken. These include, for example, other means against benign prostate enlargement, some antihypertensives, antidepressants Mirtazapine and mianserin and certain Parkinson’s drugs (dopamine agonists such as Bromocriptine, cabergoline, pergolide, apomorphine).
Patients with severe hepatic impairment should not take Alfuzosin.
The combined intake of Alfuzosin and other anti-hypertensives or anginal drugs should be used with caution. These drugs include especially nitrates (ISDN, nitroglycerin, molsidomine), beta blockers (Metoprolol, Bisoprolol), calcium antagonists (Verapamil, Diltiazem, Nifedipine), ACE inhibitors (Captopril, Enalapril, Ramipril) and sartans (Candesartan, Valsartan).
Alfuzosin is metabolized by the liver enzyme cytochrome 3A4. This split also other drugs. With simultaneous use of such drugs to the degradation of Alfuzosin can be inhibited, so that the drug accumulate in the body and can cause an increased hypotensive effect. Examples of such drugs are especially antifungals (ketoconazole, itraconazole) and HIV medicines (ritonavir).
For scheduled surgeries under anesthesia Alfuzosin should be discontinued at least one day in advance. During anesthesia, it may otherwise lead to unpredictable fluctuations in blood pressure.
The effect of Alfuzosin in children and adolescents has not been established, which is why the drug should not be used with them.
For pregnant and nursing mothers should not take the drug. He is only allowed for men (with benign prostatic hyperplasia).
How to obtain drugs with Alfuzosin
preparations containing the active substance Alfuzosin require a prescription. So You get it only after doctor’s prescription in the pharmacy.
Since when Alfuzosin is known?
The active ingredient Alfuzosin was as blood pressure medication from the French pharmaceutical company Synthelabo (now Sanofi), which belonged to the cosmetic company L’Oreal, patented in 1979th For the first time in the treatment of prostate enlargement, it has been approved in Germany in 1994, in the United States until 2003. Today there are numerous generics with the active ingredient Alfuzosin .