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If you're taking donepezil, it's important to be careful when drinking alcohol. The two don't mix well and can increase your risk of feeling dizzy, confused, or even fainting. This can make you more likely to fall or have an accident. Drinking alcohol can also make your donepezil side effects worse, which could affect your liver, kidneys, or heart. To stay safe, it's best to avoid alcohol altogether or only have a little bit. Before you make any changes to your drinking habits or medications, make sure you talk to your doctor first.

It is recommended to abstain from alcohol consumption for at least 24 hours before and after taking donepezil. This is important as alcohol consumption can worsen the side effects associated with the medication, such as dizziness, drowsiness, and coordination difficulties. If you have any concerns or questions, it is best to consult with your doctor to ensure the safe and effective use of donepezil.

It is recommended to avoid drinking alcohol the night before taking donepezil as it may increase the risk of side effects such as dizziness, drowsiness, and nausea. It is best to consult with your healthcare provider for personalized advice regarding alcohol consumption and medication use.

It is not recommended to drink alcohol while taking donepezil as it may increase the risk of side effects such as dizziness, drowsiness, and confusion. It is best to consult with your healthcare provider before consuming any alcohol while taking this medication.

The elimination half-life of donepezil is approximately 70 hours.

💡 The compatibility of donepezil with alcohol is based on excerpts from the reference data in the instructions for use of the sections on compatibility and interaction of donepezil with alcohol, as well as the consequences of not following the recommendations.

⚠️ This information is for guidance only and should not be used as a basis for making decisions on whether you can or cannot combine donepezil with alcohol. Do not self-medicate! Always consult your physician before using donepezil!

The CYP3A4 isoenzyme is involved in metabolism of donepezil and, to a lesser extent — CYP2D6. Ketoconazole and quinidine, which are CYP3A4 and CYP2D6 inhibitors, respectively, inhibit metabolism of donepezil. Consequently, these and other CYP3A4 inhibitors, such as itraconazole and erythromycin, and CYP2D6 inhibitors, such as fluoxetine, may inhibit the metabolism of donepezil. In healthy volunteers, ketoconazole increased mean concentrations of donepezil by about 30%. Concomitant use of donepezil has no effect on the pharmacokinetics of ketoconazole. Isoenzyme inducers such as rifampicin, phenytoin, carbamazepine, and ethanol may cause decreased plasma concentrations of donepezil. However, the extent of such inhibitory or inducing action is unknown, so you should use such drugs in combination with donepezil with caution.