Last Updated on March 16, 2024

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What is diphenhydramine?

Diphenhydramine is in a group of medicines called antihistamines. Diphenhydramine is a first-generation anti-allergic agent (antihistamine) that acts as an antiemetic. Because he promotes as a side effect of sleep, he is also approved as a sleep aid. Here you can read everything you need to action and use of Diphenhydramine, side effects and interactions. Diphenhydramine works by helping to control allergy symptoms, such as runny nose, sneezing, and itchy, watery eyes.

What do you need to know before taking diphenhydramine?

Avoid alcohol while using diphenhydramine. Alcohol may cause dizziness and drowsiness. Pregnancy and nursing are not recommended. Discuss the use of diphenhydramine with your healthcare provider before taking the medication.

Diphenhydramine may cause sleepiness, dizziness, drowsiness and confusion.

Diphenhydramine may cause blurred vision; do not drive a vehicle or operate machinery if you experience blurred vision.

Use caution with certain medical conditions or drugs that may affect the nervous system (e.g., dementia, epilepsy, stroke, depression). Do not take it if you are taking drugs for depression or are going into surgery.

If you have epilepsy, consult your healthcare provider before taking diphenhydramine. Epilepsy medicine may also increase the effects of diphenhydramine.

What is diphenhydramine 25 mg tablets used for?

According to the manufacturer, diphenhydramine 25mg tablets are the prescription strength version of the drug and used in adults and children who may have allergic reactions to the substance or other medications.
Diphenhydramine is most commonly used to treat insomnia and anxiety. It is also used along with another medication to treat nausea. Diphenhydramine 25 mg tablets are usually taken once or twice a day, but you should discuss the dose of your medication with your healthcare provider. This medication should be used for short-term periods. Do not take this medication for more than three months without checking with your doctor.

How diphenhydramine works?

The endogenous neurotransmitter histamine plays an important role in the body’s defense reactions against invading microbes and toxins. If an infection occurs, or Low immune system venom causes so-called mast cells stored to distribute histamine and other chemical messengers. This means that the affected tissue is supplied with blood intensely. In addition, other white blood cells are attracted and blood vessels become more permeable. Not least, tissue swelling, so that immune cells can better migrate. In some cases, however, this protective immune system response is undesirable, such as when it manifests as an allergic reaction to pollen, food, or insect bites. In this case, they can be specifically suppressed by a so-called antihistamine drug, such as Diphenhydramine. This drug occupies the docking sites (receptors) on histamine in the body, so that it can no longer work. Diphenhydramine as a first-generation antihistamine (that is, as one of the earliest substances in this class) also crosses the blood-brain barrier very well. In the brain, the neurotransmitter histamine is involved in the regulation of sleep-wake rhythm – if this regulation is disrupted by antihistamines, fatigue results as a side effect. Second-generation antihistamines have difficulty crossing the blood-brain barrier, resulting in fatigue. Diphenhydramine also acts on the vomiting center in the brainstem and thus suppresses nausea and vomiting.

Increase, decrease, and withdrawal of diphenhydramine

The drug is taken in the form of its salt diphenhydramine (diphenhydramine hydrochloride) as a tablet and passes through the intestinal membrane into the bloodstream. When used as a rectal capsule, the drug enters the bloodstream on the rectal mucosa. The highest levels in the blood are reached after one to four hours. Diphenhydramine breaks down to inactive metabolites in the liver and is excreted by the kidneys with the urine. After about four hours, half of the active substance is eliminated from the body.

When diphenhydramine is used?

At the same time, there are no drugs approved with diphenhydramine in the United Kingdom to relieve allergic reactions more. Newer antihistamines are preferred because they have fewer side effects. However, diphenhydramine is still asleep and asleep than the contributing agent component of some sleeping pills. It is also still used to treat nausea and vomiting, but the related drug Dimenhydrinate is also the most commonly used here now. Diphenhydramine should be used as self-medication, even temporarily.

How diphenhydramine is used?

To treat insomnia, a tablet containing 50 milligrams of diphenhydramine is taken 30 to 15 minutes before bedtime. You should make sure that the duration of sleep is long enough, because the active ingredient still appears even the next morning and can lead to fatigue and impaired responsiveness. The duration of treatment should be several days, but a maximum of two weeks. As a remedy for nausea and vomiting, rectal Diphenhydramine should be administered exactly as suppositories in the anus. Injection may be made easier if the capsule is dampened with water. , If symptoms persist, a rectal capsule may be administered up to three times a day. Nausea and vomiting pills are less useful because sometimes they cannot even reach the intestines and release their active ingredient when vomiting.

What are the side effects of diphenhydramine?

The most common complaint after taking Diphenhydramine as a sleeping pill is fatigue, drowsiness, and impaired concentration the next day, especially after not getting enough sleep. When taken as an anti-nausea, there is usually a side effect in the form of fatigue. Other possible side effects of diphenhydramine are, for example, heartburn, blurred vision and discomfort when urinating. More rarely, skin sensitivity to strong sunlight. Sometimes there are changes in blood tests and an increase in intraocular pressure.

What should I watch for while taking diphenhydramine?

While taking diphenhydramine, do not take any sedatives or tranquilizers (sleeping pills, sedatives, pain relievers, antidepressants, or anti-seizure medications) or drink alcohol. Which otherwise excessively enhances the effects of. Also, the effects of Diphenhydramine may be enhanced when taking antihypertensive medications. Diphenhydramine and some other drugs slow conduction in the heart muscle (this is called QT interval prolongation). Has anyone already had QT prolongation ("Long QT interval syndrome") or taking medications with QT prolonging effects, Diphenhydramine should not be used – even shifted in time with other medications. Otherwise it can lead to life-threatening cardiac arrhythmias. Examples are antiarrhythmic drugs, some antibiotics, medications for malaria, other antihistamines, dehydrating agents, and medications for psychosis and schizophrenia. Do not take diphenhydramine during pregnancy and lactation. Studies have shown that it may be teratogenic and interferes with milk supply in nursing mothers. Children from the age of twelve and elderly patients should not take Diphenhydramine in reduced doses. Can otherwise lead to enlargement of the prostate gland, which threatens urinary retention. Do not drive heavy machinery or participate in traffic after taking diphenhydramine.

How to take medications with diphenhydramine?

Preparations with a single dose of up to 50 milligrams of diphenhydramine to be taken as a tablet, rectal capsule or suppository are available over-the-counter in pharmacies.

Since when is diphenhydramine known?

The active ingredient diphenhydramine was discovered in 1943 by Professor George Rivestle at the University of Cincinnati in the United States. Only three years later, it was recognized by the FDA as the first antihistamine drug. In subsequent years, a related drug, dimenhydrinate, was developed on the basis of diphenhydramine, which has a less sleep-inducing effect. In the 1960s, diphenhydramine was found to increase serotonin levels in the brain and therefore potentially effective against depression – it served as a model for the first SSRIs (selective serotonin reuptake inhibitors) Fluoxetine. There are now many generic and over-the-counter sleep medications that contain diphenhydramine.