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WHAT IS QUETIAPINE?
The drug Quetiapine is one of the atypical antipsychotics (synonym: antipsychotics), a drug group that is used in the treatment of schizophrenia and bipolar disorder. As the second generation antipsychotic drug Quetiapine has fewer serious side effects than the first antipsychotics. Here you can read everything important on the effects of Quetiapine, side effects and use.
MECHANISM OF ACTION OF QUETIAPINE
Quetiapine is D2, H1 5-HT2A, alpha and 5-HT1A receptors. Its mechanism of Action is unknown, but according to the theory of Schizophrenia effects may be associated with the drug’s Ability to reduce dopaminergic neurotransmission pathway.
One of the key chemical messengers (neurotransmitters) between nerve cells in the human brain is dopamine. Through distribution of downstream neurons can on certain selective docking (receptors) to record signals which allow in the case of dopamine feeling of motivation, joy, memory and learning, memory and purposeful movements (fine motor skills).
Too much dopamine results in an exaggerated, manic joy to schizophrenia and loss of reality. To get these exaggerated dopamine action in the handle, antipsychotic-effective drugs such as Quetiapine are used. Quetiapine binds without activating them in the brain to dopamine receptors, it blocks them so simply for existing actually in a high concentration of dopamine. This dopamine effect is regulated down to normal levels, which the patient can be brought back into reality.
After absorption in the intestine Quetiapine is metabolized extensively in the liver, but which also have the breakdown products antipsychotic effect. After about seven hours half of the active substance (after twelve hours half of the active degradation product) excreted -. Three quarters of the urine to a quarter with the chair
WHY IS THIS MEDICINE PRESCRIBED?
Quetiapine tablets and extended-release (long-acting) tablets are used to deal with the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Quetiapine tablets and extended-release tablets can also be used alone or with other drugs to treat episodes of mania (frenzied, abnormally excited or upset disposition ) or depression in patients with bipolar illness (manic depressive disorder; a disorder which causes episodes of depression, episodes of mania, depression, and other unusual moods). Additionally, quetiapine tablets and tablets are used together with other drugs to prevent episodes of depression or mania . Quetiapine tablets can also be used as well as other drugs to treat depression. Quetiapine tablets might be used as part of a therapy system to deal with schizophrenia and bipolar illness in teens and children. Quetiapine is in a class of drugs called atypical antipsychotics. It works by altering certain substances in the brain’s action.
The active ingredient is used in the treatment of schizophrenia and bipolar disorders. The latter is particularly Quetiapine for the treatment of manic episodes and depressive episodes in the difficult disease. In addition, it is used for the prevention of recurrence in those episodes when they have previously responded to the drug.
For the acute treatment Quetiapine is used in higher doses; for long-term maintenance therapy come lower doses are used.
HOW SHOULD THIS MEDICINE BE USED?
Take this medicine as directed with or without meals. By mouth, take this medicine for the treatment of depression associated with bipolar disorder as directed by your doctor.
The dose is based on your medical condition, response to therapy. Make certain to tell your doctor and pharmacist about all the products you use (such as prescription medications, nonprescription medications, and herbal products).
To Lower your chance of side effects, your physician may direct you to begin this medicine and gradually increase your dose. Follow your doctor’s instructions. Take this medicine to get the maximum benefit. To help you remember, take it.
Do not increase your dose or use this medication more Prescribed. Your condition won’t improve any faster, and your risk of side effects increase.
It is Important to continue taking this medication even when you feel good. Don’t stop taking this medicine without consulting with your physician. Some conditions may become worse when this drug is stopped. You might experience symptoms such as difficulty sleeping, nausea, headache, diarrhea. Your dose may have to be gradually decreased to reduce side effects. Report any worsening or new symptoms away.
Tell your doctor if your condition worsens or persists.
The active substance Quetiapine is mainly applied in the form of tablets. To the multiple dose, which is important for consistent blood levels to avoid at higher doses, are tablets with prolonged release (sustained release tablets) in the market.
Depending on the field. All have in common that for the initial treatment of acute mental health problems the drug over several days “crept” is – the treatment is therefore started with a very small dose and then at the full final dose that achieves the course of several days the desired Quetiapine effect , increased. For maintenance therapy, the amount of active compound is then reduced to the lowest effective dose.
The intake of the drug is carried out with or without food once or twice daily, according to the specification of the doctor.
WHAT ARE THE SIDE EFFECTS OF QUETIAPINE?
The most common (more than one in ten patients) Quetiapine side effects are drowsiness, and so-called extrapyramidal symptoms (Parkinson-like side effects).
In addition, contact at every hundredth to tenth treated Quetiapine side effects such as changes in thyroid hormone levels, elevated blood sugar levels, increase in appetite, abnormal dreams and nightmares, suicidal behavior, blurred vision, shortness of breath and indigestion.
THIS MEDICATION COMES WITH WARNINGS.?
Quetiapine may cause a serious allergic response. Symptoms may include:
- Difficulty breathing
- swelling of your tongue or throat
If you develop these symptoms, call 911 or proceed to the emergency room.
In the event that you had an allergic reaction to it do not take this medication. Taking it could be deadly (cause death).
Alcohol discussion warning
Quetiapine May cause drowsiness. The use of beverages that contain alcohol increases your risk of the side effect. Speak with your physician about whether this medication is safe for you, if you drink alcohol.
Warnings for Individuals with specific health conditions
For Those Who Have diabetes or Higher blood glucose: Quetiapine can improve. Large blood glucose can cause death or coma. Talk to your physician, For those who have diabetes or risk factors of diabetes. They ought to check your blood glucose before and during treatment.
For Those Who Have hyperlipidemia (high fat levels in the blood): Quetiapine may further boost the degree of fat (triglycerides and cholesterol ) in your blood. Fat levels increase your chance of stroke and heart attack. These levels do not cause symptoms. Your physician can check your blood glucose and cholesterol throughout treatment.
For Those Who Have low or Higher blood pressure: Your blood pressure that is high or very low can worsen. It might also raise blood pressure in teens and children. At the same time you choose quetiapine, your physician should monitor your blood pressure.
For Individuals with a low white blood cell count: Quetiapine may decrease your white blood cell count that is low more. Your physician should monitor your blood cell count often. This may help to make sure quetiapine isn’t diminishing your blood cell count.
For Individuals with Illness: Your own degeneration can worsen. You will be monitored by your health care provider . Once you begin treatment and every 6 weeks They’ll analyze your eyes.
For Those Who Have seizures: Seizures have occurred in patients without epilepsy when taking quetiapine. Quetiapine can make it more challenging to control seizures. You should be monitored by your physician to get an increase in migraines.
For Those Who Have hypothyroidism (low thyroid degree ): Thyroid hormone levels may be lowered by quetiapine and worsen your own condition. Your physician should monitor your blood thyroid hormone levels prior to and during therapy.
For individuals with heart troubles: Ask your physician if this medication is safe for you. The risk of abnormal heart rhythms increases.
For Individuals with liver problems: Quetiapine is broken down into the body by the liver. Because of this, individuals with liver problems could have increased blood levels of the medication. This increases the probability of side effects.
Warnings for Different groups
For elderly women: Quetiapine is a category C pregnancy medication. Which means two things:
- Research in animals has shown adverse consequences to the fetus once the mother takes the medication.
- There have not been enough research done in people to be sure how the drug might affect the fetus.
Talk To your doctor if you are intending to get pregnant or pregnant. This medication should be used if the possible benefit justifies the possible risk.
For women That Are breastfeeding: Quetiapine can pass into breast milk and might cause unwanted effects. Speak with your health care provider if you breastfeed your child. You might want to determine whether to quit breastfeeding or discontinue taking this medicine.
For seniors: The kidneys And livers of older adults might not do the job and they used to. This may cause the human body to process drugs. Because of this, a greater volume of a drug remains in the body for a period. This increases your chance of unwanted effects.
- Episodes: This medicine has not been examined in children for this use. It should not be used in children younger than 13 decades.
- Bipolar I mania
- Episodes: This medicine has not been studied in children for this purpose. It should not be used in children younger than ten decades.
- Bipolar disease, manic episodes: This medicine has not been examined in children for this use. It should not be used in children younger than 18 decades.
- Major depressive disorder treated with antidepressants: This medicine has not been examined in children for this use. It should not be used in children younger than 18 decades.
Quetiapine acts primarily in the central nervous system, which is why the use of other centrally acting drugs should be carried out previously clarified and with caution. The same applies to the consumption of alcohol.
The drug is mainly metabolized by the so-called CYP enzyme system in the liver that breaks down many other drugs in the body. Specifically, the enzyme CYP3A4, which metabolizes Quetiapine, relieves many other active ingredients. If these taken simultaneously, an active ingredient is usually primarily degraded, while the other accumulates in the body. The possible consequences are an undesirably high concentration up to toxicity.
Other agents make with concurrent use that Quetiapine is degraded more rapidly and thus poorly or not acting. Examples of such drugs are ketoconazole (for fungal infections) and Carbamazepine and Phenytoin (for epilepsy).
treatment with Quetiapine is not recommended for children and adolescents under 18 years, the absence of any data.
In the elderly, elimination is slowed from the body, so the dose should be reduced so that the drug does not accumulate in the body. The same applies to patients with hepatic impairment.
Pregnancy and lactation
Since the safety of taking Quetiapine during pregnancy has not been established, pregnant women should not take the drug. He will also pass into breast milk, so nursing mothers also should not take the drug. If a dose strictly necessary, should be discontinued.
HOW TO GET QUETIAPINE?
Quetiapine is in each dose prescription and only on presentation of a prescription at the pharmacy to buy.
SINCE WHEN QUETIAPINE IS KNOWN?
The drug was discovered by the pharmaceutical company AstraZeneca in the years 1992 to 1996 as a further development of the first generation of antipsychotics (typical neuroleptics) and explored. In 1997, he was admitted into the United States. The patent expired in 2012 from: since reached numerous generics with the drug Quetiapine on the market.