Last Updated on March 16, 2024
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Buspirone
Buspirone is an anxiolytic agent and a remedy for the treatment of anxiety states of various origins, especially neuroses, accompanied by anxiety, anxiety, irritability. The mechanism of action of buspirone has not been finally established, but it is known that it differs from the mechanism of action of benzodiazepines and other anxiolytic agents. For this purpose, he intervenes in the metabolism of the neurotransmitter serotonin in the brain substance. Unlike benzodiazepines (also anxiolytic) acts Buspirone only after a few weeks, makes it but not tired and – after prolonged intake – dependent. Here you can read all you need to know about effects and application of Buspirone, side effects and interactions.
How Buspirone works
In anxiety disorders, a patient suffering from a persistent and difficulty sleeping.
Anxiolytic drugs such as benzodiazepines (hydroxyzine, lorazepam and others) quickly and reliably relieve the mental and physical ailments. However, they can lead to dependence quickly (usually after some weeks). Will they discontinued the original symptoms heavier than before again.
Unlike the drug Buspirone: he occupied for several weeks, begin the complex neural structures of the brain that can trigger anxiety disorders, to reorganize itself. Namely, by Buspirone certain docking sites (receptors) of the neurotransmitter serotonin substance activated, changes the “interconnection” of nerve cells as studies show. This fact also explains the delayed onset of action until the fear solver. Buspirone acts not only on different receptors of the “happiness hormone” serotonin and those of, but also to mentally drive-increasing receptors for norepinephrine.
In addition to the treatment with Buspirone anxiety patients should always make a psychotherapy.
Pharmacokinetics and metabolism of Buspirone
After his taking the drug is absorbed quickly and completely into the bloodstream through the intestinal wall. From the intestine it passes with the blood in the liver, where it is deactivated to about 95 percent (“first pass metabolism”). The Buspirone blood levels, which till a half hour reaches its maximum one after taking it, therefore, declined again by half after about two to three hours. The degradation products of Buspirone are excreted about two-thirds of the urine and one-third with the chair.
When is Buspirone used?
The drug Buspirone is approved for the symptomatic treatment of anxiety which are characterized particularly by fear, anxiety and stress states.
Although Buspirone does not lead to addiction, anxiety solver should be used for no longer than four months.
How to take Buspirone
The intake of Buspirone occurs in tablet form. The total daily dose is divided into three single doses, which are taken without regard to meals with a glass of water. The initiation of treatment carried creeping in: It is therefore taken at the beginning of a low dose (usually three times a day five milligrams), which is then slowly increased depending on the effect and the occurrence of side effects (on ten milligrams three times a day). In severe cases, the doctor may increase the dose up to three times 20 milligrams per day.
What are the side effects Buspirone?
During the treatment, show up at one of tens to hundreds of patients side effects like chest pain, nightmares, anger, hostility, confusion, drowsiness, ringing in the ears, sore throat, stuffy nose, blurred vision, muscle pain, paresthesia, skin rashes, and increased sweating.
What should I watch for while taking Buspirone?
Although in clinical trials, no interactions between alcohol and Buspirone were observed, should generally be consumed during treatment with psychotropic drugs, no alcohol.
There are no studies on possible interactions between Buspirone and other psychotropic drugs (such as neuroleptics / antipsychotics, antidepressants). Before co-administration should therefore be consulted always an experienced physician. The same applies to combinations with hormonal contraceptives, anticoagulants, agents for diabetes and other active ingredients.
Remedy for depression from the class of monoamine oxidase inhibitors (MAOIs) should not be combined with Buspirone, as this may lead to acute hypertension crises.
You may be affected by taking Buspirone responsiveness. Therefore, patients should be used during treatment operate heavy machinery and not drive cars.
There is no experience on the use of Buspirone during pregnancy and lactation, and in children and adolescents before. In these stages of life of the anxiety drug should not be taken.
How to buy medication with Buspirone
All the preparations with the anxiety drug Buspirone are pharmacy and prescription. So You get it only with a doctor’s prescription. But You may get prescription online and buy Buspirone 5 & 10 mg online over the counter.
How long has Buspirone known?
The active ingredient Buspirone was by a team of scientists from the Mead Johnson Nutrition Company (a manufacturer of baby food) discovered in the year 1972nd However, it was patented in 1975 and 1986 brought by the pharmaceutical company Bristol-Myers Squibb in the US market. In Germany, the approval was granted in 1996. In 2001, patent protection expired. Meanwhile, there is also a generic product containing the active substance Buspirone .