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Mixing alcohol with sertraline, a medication that helps with anxiety and depression, can lead to a higher chance of problems like feeling dizzy, sleepy, or making bad choices. It can make anxiety or depression even worse, too. Both alcohol and sertraline are processed by the liver, and when you use them together, it could damage your liver. That's why it's essential to steer clear of alcohol when taking sertraline. Drinking while taking sertraline can impact your brain, liver, and kidneys, so it's best to avoid putting yourself at risk.

Drinking alcohol could make certain side effects of the medication more likely to occur. It's best to avoid drinking alcohol for several hours before and after taking the medication.

It is not recommended to consume alcohol the night before taking sertraline. It can increase the risk of certain side effects such as drowsiness, dizziness, and impaired coordination. Additionally, alcohol can worsen symptoms of depression and anxiety, which sertraline is commonly prescribed to treat. Therefore, it is best to avoid drinking alcohol before or during treatment with sertraline.

The elimination half-life of sertraline is approximately 26 hours.